Factors of increase in serum triglyceride-rich lipoproteins in uremic rats

Jean-Baptiste Roullet, B. Lacour, J. P. Yvert, J. J. Prat, T. Drueke

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The possible mechanisms of the increase in serum triglycerides (TG) and TG-rich lipoproteins were studied in chronically uremic (U) rats by comparison with either ad-lib fed control (C) rats or diet-restricted (DR), sham-operated pair-fed control rats. A first series of animals was studied in the fed state and a second series after a 16-hr fast. In U animals the concentration of serum TG and TG-rich particles was lower than that of C rats in the fed state but significantly higher than that of C and DR rats after a 16-hr fast. Serum glucose and lactate concentrations in the fed or fasted state were unchanged by uremia. Serum insulin concentration was significantly decreased in U rats as compared to C and DR rats in both series. The fast did not increase the concentration of serum nonesterified fatty acids (NEFA) in U or DR animals to the same extent as in C rats, whereas the serum concentration of β-hydroxybutyrate (BOB), which was higher than that of C rats in the fed state, was significantly lower after a 16-hr fast. In U animals, as compared to control rats of either series, a significant decrease of epididymal lipoprotein lipase (LPL) activity was observed during both nutritional states when expressing the enzymic activity per number of cells. In conclusion, our data provide evidence against hepatic overproduction of TG-rich lipoproteins in rats with chronic renal failure and strongly point to an LPL-mediated defect of their peripheral catabolism, probably related to the insulin deficiency state.

Original languageEnglish (US)
Pages (from-to)420-425
Number of pages6
JournalKidney International
Volume27
Issue number2
StatePublished - 1985
Externally publishedYes

Fingerprint

Lipoproteins
Triglycerides
Serum
Diet
Lipoprotein Lipase
Insulin
Hydroxybutyrates
Uremia
Nonesterified Fatty Acids
Chronic Kidney Failure
Lactic Acid
Cell Count
Glucose
Liver

ASJC Scopus subject areas

  • Nephrology

Cite this

Roullet, J-B., Lacour, B., Yvert, J. P., Prat, J. J., & Drueke, T. (1985). Factors of increase in serum triglyceride-rich lipoproteins in uremic rats. Kidney International, 27(2), 420-425.

Factors of increase in serum triglyceride-rich lipoproteins in uremic rats. / Roullet, Jean-Baptiste; Lacour, B.; Yvert, J. P.; Prat, J. J.; Drueke, T.

In: Kidney International, Vol. 27, No. 2, 1985, p. 420-425.

Research output: Contribution to journalArticle

Roullet, J-B, Lacour, B, Yvert, JP, Prat, JJ & Drueke, T 1985, 'Factors of increase in serum triglyceride-rich lipoproteins in uremic rats', Kidney International, vol. 27, no. 2, pp. 420-425.
Roullet J-B, Lacour B, Yvert JP, Prat JJ, Drueke T. Factors of increase in serum triglyceride-rich lipoproteins in uremic rats. Kidney International. 1985;27(2):420-425.
Roullet, Jean-Baptiste ; Lacour, B. ; Yvert, J. P. ; Prat, J. J. ; Drueke, T. / Factors of increase in serum triglyceride-rich lipoproteins in uremic rats. In: Kidney International. 1985 ; Vol. 27, No. 2. pp. 420-425.
@article{ab7914e8e92048f4a5b2f01bbb5a5b81,
title = "Factors of increase in serum triglyceride-rich lipoproteins in uremic rats",
abstract = "The possible mechanisms of the increase in serum triglycerides (TG) and TG-rich lipoproteins were studied in chronically uremic (U) rats by comparison with either ad-lib fed control (C) rats or diet-restricted (DR), sham-operated pair-fed control rats. A first series of animals was studied in the fed state and a second series after a 16-hr fast. In U animals the concentration of serum TG and TG-rich particles was lower than that of C rats in the fed state but significantly higher than that of C and DR rats after a 16-hr fast. Serum glucose and lactate concentrations in the fed or fasted state were unchanged by uremia. Serum insulin concentration was significantly decreased in U rats as compared to C and DR rats in both series. The fast did not increase the concentration of serum nonesterified fatty acids (NEFA) in U or DR animals to the same extent as in C rats, whereas the serum concentration of β-hydroxybutyrate (BOB), which was higher than that of C rats in the fed state, was significantly lower after a 16-hr fast. In U animals, as compared to control rats of either series, a significant decrease of epididymal lipoprotein lipase (LPL) activity was observed during both nutritional states when expressing the enzymic activity per number of cells. In conclusion, our data provide evidence against hepatic overproduction of TG-rich lipoproteins in rats with chronic renal failure and strongly point to an LPL-mediated defect of their peripheral catabolism, probably related to the insulin deficiency state.",
author = "Jean-Baptiste Roullet and B. Lacour and Yvert, {J. P.} and Prat, {J. J.} and T. Drueke",
year = "1985",
language = "English (US)",
volume = "27",
pages = "420--425",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Factors of increase in serum triglyceride-rich lipoproteins in uremic rats

AU - Roullet, Jean-Baptiste

AU - Lacour, B.

AU - Yvert, J. P.

AU - Prat, J. J.

AU - Drueke, T.

PY - 1985

Y1 - 1985

N2 - The possible mechanisms of the increase in serum triglycerides (TG) and TG-rich lipoproteins were studied in chronically uremic (U) rats by comparison with either ad-lib fed control (C) rats or diet-restricted (DR), sham-operated pair-fed control rats. A first series of animals was studied in the fed state and a second series after a 16-hr fast. In U animals the concentration of serum TG and TG-rich particles was lower than that of C rats in the fed state but significantly higher than that of C and DR rats after a 16-hr fast. Serum glucose and lactate concentrations in the fed or fasted state were unchanged by uremia. Serum insulin concentration was significantly decreased in U rats as compared to C and DR rats in both series. The fast did not increase the concentration of serum nonesterified fatty acids (NEFA) in U or DR animals to the same extent as in C rats, whereas the serum concentration of β-hydroxybutyrate (BOB), which was higher than that of C rats in the fed state, was significantly lower after a 16-hr fast. In U animals, as compared to control rats of either series, a significant decrease of epididymal lipoprotein lipase (LPL) activity was observed during both nutritional states when expressing the enzymic activity per number of cells. In conclusion, our data provide evidence against hepatic overproduction of TG-rich lipoproteins in rats with chronic renal failure and strongly point to an LPL-mediated defect of their peripheral catabolism, probably related to the insulin deficiency state.

AB - The possible mechanisms of the increase in serum triglycerides (TG) and TG-rich lipoproteins were studied in chronically uremic (U) rats by comparison with either ad-lib fed control (C) rats or diet-restricted (DR), sham-operated pair-fed control rats. A first series of animals was studied in the fed state and a second series after a 16-hr fast. In U animals the concentration of serum TG and TG-rich particles was lower than that of C rats in the fed state but significantly higher than that of C and DR rats after a 16-hr fast. Serum glucose and lactate concentrations in the fed or fasted state were unchanged by uremia. Serum insulin concentration was significantly decreased in U rats as compared to C and DR rats in both series. The fast did not increase the concentration of serum nonesterified fatty acids (NEFA) in U or DR animals to the same extent as in C rats, whereas the serum concentration of β-hydroxybutyrate (BOB), which was higher than that of C rats in the fed state, was significantly lower after a 16-hr fast. In U animals, as compared to control rats of either series, a significant decrease of epididymal lipoprotein lipase (LPL) activity was observed during both nutritional states when expressing the enzymic activity per number of cells. In conclusion, our data provide evidence against hepatic overproduction of TG-rich lipoproteins in rats with chronic renal failure and strongly point to an LPL-mediated defect of their peripheral catabolism, probably related to the insulin deficiency state.

UR - http://www.scopus.com/inward/record.url?scp=0021987801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021987801&partnerID=8YFLogxK

M3 - Article

C2 - 3886997

AN - SCOPUS:0021987801

VL - 27

SP - 420

EP - 425

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 2

ER -