Factors associated with primary vein graft occlusion in a multicenter trial with mandated ultrasound surveillance

Lawrence Oresanya, Anil N. Makam, Michael Belkin, Gregory (Greg) Moneta, Michael S. Conte

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Objective Even in the setting of duplex ultrasound (DUS) surveillance, a significant number of lower extremity vein bypass grafts (LEVBGs) become occluded as a first event. We sought to identify factors that may contribute to these primary occlusions. Methods This was a retrospective analysis of the Project of Ex Vivo Graft Engineering via Transfection III (PREVENT III) multicenter randomized clinical trial, in which 1404 patients with critical limb ischemia (CLI) underwent LEVBG with 1-year follow-up. Subjects were to undergo DUS at regular intervals (1, 3, 6, and 12 months), with reintervention based on prespecified DUS criteria. Patients who had nontechnical graft occlusion as the initial graft-related event were identified, and multivariate analysis was used to determine factors associated with primary graft occlusion. Results Primary vein graft occlusion occurred in 200 subjects and accounted for 36% of all primary patency events and 64% of all graft occlusions in the trial. Primary occlusion events were evenly distributed throughout the first postoperative year. Rates of recurrent CLI, loss of secondary patency, and major amputation in those with primary occlusion were 55%, 79%, and 22% respectively as compared to 18%, 10%, and 10% for subjects without primary occlusion (P

    Original languageEnglish (US)
    Pages (from-to)996-1002
    Number of pages7
    JournalJournal of Vascular Surgery
    Volume59
    Issue number4
    DOIs
    StatePublished - 2014

    Fingerprint

    Multicenter Studies
    Veins
    Transplants
    Lower Extremity
    Ischemia
    Extremities
    Amputation
    Transfection
    Multivariate Analysis
    Randomized Controlled Trials

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Surgery

    Cite this

    Factors associated with primary vein graft occlusion in a multicenter trial with mandated ultrasound surveillance. / Oresanya, Lawrence; Makam, Anil N.; Belkin, Michael; Moneta, Gregory (Greg); Conte, Michael S.

    In: Journal of Vascular Surgery, Vol. 59, No. 4, 2014, p. 996-1002.

    Research output: Contribution to journalArticle

    Oresanya, Lawrence ; Makam, Anil N. ; Belkin, Michael ; Moneta, Gregory (Greg) ; Conte, Michael S. / Factors associated with primary vein graft occlusion in a multicenter trial with mandated ultrasound surveillance. In: Journal of Vascular Surgery. 2014 ; Vol. 59, No. 4. pp. 996-1002.
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    abstract = "Objective Even in the setting of duplex ultrasound (DUS) surveillance, a significant number of lower extremity vein bypass grafts (LEVBGs) become occluded as a first event. We sought to identify factors that may contribute to these primary occlusions. Methods This was a retrospective analysis of the Project of Ex Vivo Graft Engineering via Transfection III (PREVENT III) multicenter randomized clinical trial, in which 1404 patients with critical limb ischemia (CLI) underwent LEVBG with 1-year follow-up. Subjects were to undergo DUS at regular intervals (1, 3, 6, and 12 months), with reintervention based on prespecified DUS criteria. Patients who had nontechnical graft occlusion as the initial graft-related event were identified, and multivariate analysis was used to determine factors associated with primary graft occlusion. Results Primary vein graft occlusion occurred in 200 subjects and accounted for 36{\%} of all primary patency events and 64{\%} of all graft occlusions in the trial. Primary occlusion events were evenly distributed throughout the first postoperative year. Rates of recurrent CLI, loss of secondary patency, and major amputation in those with primary occlusion were 55{\%}, 79{\%}, and 22{\%} respectively as compared to 18{\%}, 10{\%}, and 10{\%} for subjects without primary occlusion (P",
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    AU - Belkin, Michael

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    AU - Conte, Michael S.

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    N2 - Objective Even in the setting of duplex ultrasound (DUS) surveillance, a significant number of lower extremity vein bypass grafts (LEVBGs) become occluded as a first event. We sought to identify factors that may contribute to these primary occlusions. Methods This was a retrospective analysis of the Project of Ex Vivo Graft Engineering via Transfection III (PREVENT III) multicenter randomized clinical trial, in which 1404 patients with critical limb ischemia (CLI) underwent LEVBG with 1-year follow-up. Subjects were to undergo DUS at regular intervals (1, 3, 6, and 12 months), with reintervention based on prespecified DUS criteria. Patients who had nontechnical graft occlusion as the initial graft-related event were identified, and multivariate analysis was used to determine factors associated with primary graft occlusion. Results Primary vein graft occlusion occurred in 200 subjects and accounted for 36% of all primary patency events and 64% of all graft occlusions in the trial. Primary occlusion events were evenly distributed throughout the first postoperative year. Rates of recurrent CLI, loss of secondary patency, and major amputation in those with primary occlusion were 55%, 79%, and 22% respectively as compared to 18%, 10%, and 10% for subjects without primary occlusion (P

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