Factors associated with blood loss during radical prostatectomy for localized prostate cancer in the prostate-specific antigen (PSA)-era: An overview of the department of defense (DOD) Center for Prostate Disease Research (CPDR) national database

Judd W. Moul, Leon Sun, Hongyu Wu, David G. McLeod, Christopher Amling, Raymond Lance, John Foley, Wade Sexton, Leo Kusuda, Andrew Chung, Douglas Soderdahl, Timothy Donahue

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Radical Prostatectomy (RP) has been traditionally associated with significant operative blood loss and high risk of transfusion. However, over the last few years, centers of excellence have reported less bleeding and transfusion. To verify and document changes in the epidemiology of bleeding and transfusion of men electing RP, we undertook an analysis of such cases in the Department of Defense (DoD) Center for Prostate Disease Research (CPDR) Multicenter Research Database. Using the Department of Defense Center for Prostate Disease Research (CPDR) Multicenter National Research Database, a query of all RPs performed between January 1, 1985 and December 31, 2000 was conducted revealing 2918 cases with blood-loss data available for analysis from nine hospital sites. These cases were analyzed over time (calendar year) and changes in the characteristics of the patients, disease severity, and surgical results were compared with estimated blood loss (EBL) and transfusion data. Among the 2918 evaluable men, 2399 (82%) underwent a retropubic RP, 97% had clinical T1-2 disease, and 77% had a PSA level ≥10.0 ng/mL. Overall median operation time was 3.8 h, and EBL was 1000 cc. Examining trends over time, there was a dramatic decline in median operative time, EBL, and transfusion rate. In multiple linear regression analysis, operative time, operative approach, surgery year, lymphadenectomy status, and neoadjuvant hormonal therapy were significant predictor of EBL. Blood loss difference between retropubic and perineal RP became insignificant in the latter years. Radical prostatectomy is being performed more commonly on men with earlier stage disease in the PSA-Era. The operation is now performed more rapidly with less blood loss and fewer transfusion requirements. In a broad practice experience represented here, autologous blood donation would appear to be unnecessary for the majority of men and the blood loss advantage traditionally associated with perineal RP is no longer evident.

Original languageEnglish (US)
Pages (from-to)447-455
Number of pages9
JournalUrologic Oncology: Seminars and Original Investigations
Volume21
Issue number6
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Prostate-Specific Antigen
Prostatectomy
Prostate
Prostatic Neoplasms
Databases
Research
Operative Time
Blood Transfusion
Hemorrhage
Neoadjuvant Therapy
Lymph Node Excision
Blood Donors
Linear Models
Epidemiology
Regression Analysis

Keywords

  • Blood
  • Prostate cancer
  • Radical prostatectomy
  • Transfusion

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Factors associated with blood loss during radical prostatectomy for localized prostate cancer in the prostate-specific antigen (PSA)-era : An overview of the department of defense (DOD) Center for Prostate Disease Research (CPDR) national database. / Moul, Judd W.; Sun, Leon; Wu, Hongyu; McLeod, David G.; Amling, Christopher; Lance, Raymond; Foley, John; Sexton, Wade; Kusuda, Leo; Chung, Andrew; Soderdahl, Douglas; Donahue, Timothy.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 21, No. 6, 11.2003, p. 447-455.

Research output: Contribution to journalArticle

Moul, Judd W. ; Sun, Leon ; Wu, Hongyu ; McLeod, David G. ; Amling, Christopher ; Lance, Raymond ; Foley, John ; Sexton, Wade ; Kusuda, Leo ; Chung, Andrew ; Soderdahl, Douglas ; Donahue, Timothy. / Factors associated with blood loss during radical prostatectomy for localized prostate cancer in the prostate-specific antigen (PSA)-era : An overview of the department of defense (DOD) Center for Prostate Disease Research (CPDR) national database. In: Urologic Oncology: Seminars and Original Investigations. 2003 ; Vol. 21, No. 6. pp. 447-455.
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abstract = "Radical Prostatectomy (RP) has been traditionally associated with significant operative blood loss and high risk of transfusion. However, over the last few years, centers of excellence have reported less bleeding and transfusion. To verify and document changes in the epidemiology of bleeding and transfusion of men electing RP, we undertook an analysis of such cases in the Department of Defense (DoD) Center for Prostate Disease Research (CPDR) Multicenter Research Database. Using the Department of Defense Center for Prostate Disease Research (CPDR) Multicenter National Research Database, a query of all RPs performed between January 1, 1985 and December 31, 2000 was conducted revealing 2918 cases with blood-loss data available for analysis from nine hospital sites. These cases were analyzed over time (calendar year) and changes in the characteristics of the patients, disease severity, and surgical results were compared with estimated blood loss (EBL) and transfusion data. Among the 2918 evaluable men, 2399 (82{\%}) underwent a retropubic RP, 97{\%} had clinical T1-2 disease, and 77{\%} had a PSA level ≥10.0 ng/mL. Overall median operation time was 3.8 h, and EBL was 1000 cc. Examining trends over time, there was a dramatic decline in median operative time, EBL, and transfusion rate. In multiple linear regression analysis, operative time, operative approach, surgery year, lymphadenectomy status, and neoadjuvant hormonal therapy were significant predictor of EBL. Blood loss difference between retropubic and perineal RP became insignificant in the latter years. Radical prostatectomy is being performed more commonly on men with earlier stage disease in the PSA-Era. The operation is now performed more rapidly with less blood loss and fewer transfusion requirements. In a broad practice experience represented here, autologous blood donation would appear to be unnecessary for the majority of men and the blood loss advantage traditionally associated with perineal RP is no longer evident.",
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AU - Sun, Leon

AU - Wu, Hongyu

AU - McLeod, David G.

AU - Amling, Christopher

AU - Lance, Raymond

AU - Foley, John

AU - Sexton, Wade

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