Factors Affecting Stereotactic Accuracy in Image-Guided Deep Brain Stimulator Electrode Placement

Andrew L. Ko, Aly Ibrahim, Philippe Magown, Rebecca Macallum, Kim Burchiel

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background/Aims: Intraoperative imaging allows near-real-time assessment of stereotactic accuracy during implantation of deep brain stimulation (DBS) electrodes. Such technology can be used to examine factors impacting stereotactic error. Methods: Intraoperative CT imaging was reviewed in patients undergoing DBS placement at Oregon Health and Sciences University. Coordinates of the target electrode were compared to the operative plan to characterize the magnitude and direction of stereotactic error with respect to side of implantation, target, and electrode approach angles. Results: One hundred sixty-nine leads in 94 patients were examined. Targets were GPi (n = 86), STN (n = 31), and Vim (n = 52). The average Euclidean error was 1.63 mm (SD 0.87). The error magnitude was higher for Vim (1.95 mm) than for GPi (1.44 mm), while STN (1.65 mm) did not differ from either Vim or GPi (ANOVA: F = 6.15, p = 0.003). Electrodes targeting Vim and STN were significantly more likely to deviate medially compared to those targeting GPi (ANOVA: F = 9.13, p < 0.001). The coronal approach angle affected the error when targeting Vim (ρ = 0.338, p = 0.01). These findings were confirmed during multivariate analyses. Conclusions: This study shows a significant effect of target on the accuracy of electrode placement for DBS. Targeting Vim results in a greater Euclidean error and a greater medial deviation off target. These systematic deviations should be taken into account during electrode implantation.

Original languageEnglish (US)
Pages (from-to)315-324
Number of pages10
JournalStereotactic and Functional Neurosurgery
DOIs
StateAccepted/In press - Sep 9 2017

Keywords

  • Deep brain stimulation
  • Image-guided deep brain stimulation
  • Stereotactic error

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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