Facilitation of nicotinic response in the guinea pig prevertebral neurons by substance P

Zhi-Gen Jiang, N. J. Dun

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Fast excitatory postsynaptic potentials (f-EPSPs) evoked in guinea-pig inferior mesenteric ganglion cells were augmented during the course of non-cholinergic EPSP which is thought to be mediated by a substance P (SP)-like peptide. SP applied exogenously likewise increased the f-EPSPs and nicotinic depolarizations induced by acetylcholine applied by pressure ejection. Contrary to several earlier studies where SP was reported to interfere with nicotinic receptor activation, our results show that the peptide facilitates nicotinic transmission in the inferior mesenteric ganglia.

Original languageEnglish (US)
Pages (from-to)196-198
Number of pages3
JournalBrain Research
Volume363
Issue number1
DOIs
StatePublished - Jan 15 1986
Externally publishedYes

Fingerprint

Excitatory Postsynaptic Potentials
Substance P
Guinea Pigs
Neurons
Ganglia
Nicotinic Receptors
Acetylcholine
Pressure
Peptides

Keywords

  • inferior mesenteric ganglion
  • nicotinic transmission
  • substance P

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Facilitation of nicotinic response in the guinea pig prevertebral neurons by substance P. / Jiang, Zhi-Gen; Dun, N. J.

In: Brain Research, Vol. 363, No. 1, 15.01.1986, p. 196-198.

Research output: Contribution to journalArticle

Jiang, Zhi-Gen ; Dun, N. J. / Facilitation of nicotinic response in the guinea pig prevertebral neurons by substance P. In: Brain Research. 1986 ; Vol. 363, No. 1. pp. 196-198.
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