Facilitation of nicotinic response in the guinea pig prevertebral neurons by substance P

Z. G. Jiang, N. J. Dun

Research output: Contribution to journalArticle

8 Scopus citations


Fast excitatory postsynaptic potentials (f-EPSPs) evoked in guinea-pig inferior mesenteric ganglion cells were augmented during the course of non-cholinergic EPSP which is thought to be mediated by a substance P (SP)-like peptide. SP applied exogenously likewise increased the f-EPSPs and nicotinic depolarizations induced by acetylcholine applied by pressure ejection. Contrary to several earlier studies where SP was reported to interfere with nicotinic receptor activation, our results show that the peptide facilitates nicotinic transmission in the inferior mesenteric ganglia.

Original languageEnglish (US)
Pages (from-to)196-198
Number of pages3
JournalBrain research
Issue number1
StatePublished - Jan 15 1986



  • inferior mesenteric ganglion
  • nicotinic transmission
  • substance P

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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