Facilitation and disruption of the long-term store of memory with neural excitants

John Jr Crabbe, Herbert P. Alpern

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Male hybrid mice (C57BL/6J × DBA/2J) were trained for 2 days in a 6-unit brightness discrimination maze. Beginning 24 hr after training, mice were administered daily injections of strychnine sulphate, Metrazol, d-amphetamine sulphate, caffeine citrate, nicotine alkaloid, or saline for 5 days. Forty-eight hr after the injection series was completed, mice were trained to criterion in the maze. Mice administered strychnine sulphate or Metrazol showed significantly better retention than those administered saline while mice administered d-amphetamine sulphate were significantly poorer. Nicotine alkaloid produced a trend toward facilitation, while caffeine citrate had no effect. The observed facilitation and disruption were not due to enhancement or impairment of learning ability and could not be attributed to effects upon the consolidation process.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume1
Issue number2
DOIs
StatePublished - 1973
Externally publishedYes

Fingerprint

Strychnine
Dextroamphetamine
Pentylenetetrazole
Long-Term Memory
Nicotine
Alkaloids
Sulfates
Data storage equipment
Consolidation
Luminance
Injections
Aptitude
Inbred C57BL Mouse
Learning
caffeine citrate

Keywords

  • Analeptics
  • d-Amphetamine
  • Long-term memory store
  • Memory
  • Memory disruption
  • Memory facilitation
  • Metrazol
  • Pentylenetetrazol
  • Strychnine

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology
  • Medicine(all)

Cite this

Facilitation and disruption of the long-term store of memory with neural excitants. / Crabbe, John Jr; Alpern, Herbert P.

In: Pharmacology, Biochemistry and Behavior, Vol. 1, No. 2, 1973, p. 197-202.

Research output: Contribution to journalArticle

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