Facilitation and disruption of the long-term store of memory with neural excitants

John C. Crabbe, Herbert P. Alpern

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Male hybrid mice (C57BL/6J × DBA/2J) were trained for 2 days in a 6-unit brightness discrimination maze. Beginning 24 hr after training, mice were administered daily injections of strychnine sulphate, Metrazol, d-amphetamine sulphate, caffeine citrate, nicotine alkaloid, or saline for 5 days. Forty-eight hr after the injection series was completed, mice were trained to criterion in the maze. Mice administered strychnine sulphate or Metrazol showed significantly better retention than those administered saline while mice administered d-amphetamine sulphate were significantly poorer. Nicotine alkaloid produced a trend toward facilitation, while caffeine citrate had no effect. The observed facilitation and disruption were not due to enhancement or impairment of learning ability and could not be attributed to effects upon the consolidation process.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Issue number2
StatePublished - 1973


  • Analeptics
  • Long-term memory store
  • Memory
  • Memory disruption
  • Memory facilitation
  • Metrazol
  • Pentylenetetrazol
  • Strychnine
  • d-Amphetamine

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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