Facile one-pot synthesis of polymer-phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy

Matthew A. Nakatsuka, Joo Hye Lee, Emi Nakayama, Albert M. Hung, Mark J. Hsu, Robert F. Mattrey, Sadik C. Esener, Jennifer N. Cha, Andrew P. Goodwin

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

This paper reports the one-pot synthesis of perfluorocarbon microbubbles with crosslinked shells of poly(acrylic acid) and phospholipid that boast excellent ultrasound contrast enhancement, enhanced loading capacity, and the ability to retain or release their contents through variation in the level of ultrasound exposure.

Original languageEnglish (US)
Pages (from-to)1656-1659
Number of pages4
JournalSoft Matter
Volume7
Issue number5
DOIs
StatePublished - Mar 7 2011

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

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    Nakatsuka, M. A., Lee, J. H., Nakayama, E., Hung, A. M., Hsu, M. J., Mattrey, R. F., Esener, S. C., Cha, J. N., & Goodwin, A. P. (2011). Facile one-pot synthesis of polymer-phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy. Soft Matter, 7(5), 1656-1659. https://doi.org/10.1039/c0sm01131b