Facile one-pot synthesis of polymer-phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy

Matthew A. Nakatsuka; Joo Hye Lee; Emi Nakayama; Albert M. Hung; Mark J. Hsu; Robert F. Mattrey; Sadik C. Esener; Jennifer N. Cha; Andrew P. Goodwin

doi:10.1039/c0sm01131b

Facile one-pot synthesis of polymer-phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy

Matthew A. Nakatsuka, Joo Hye Lee, Emi Nakayama, Albert M. Hung, Mark J. Hsu, Robert F. Mattrey, Sadik C. Esener, Jennifer N. Cha, Andrew P. Goodwin

Knight Cancer Institute

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

This paper reports the one-pot synthesis of perfluorocarbon microbubbles with crosslinked shells of poly(acrylic acid) and phospholipid that boast excellent ultrasound contrast enhancement, enhanced loading capacity, and the ability to retain or release their contents through variation in the level of ultrasound exposure.

Original language	English (US)
Pages (from-to)	1656-1659
Number of pages	4
Journal	Soft Matter
Volume	7
Issue number	5
DOIs	https://doi.org/10.1039/c0sm01131b
State	Published - Mar 7 2011

ASJC Scopus subject areas

Chemistry(all)
Condensed Matter Physics

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10.1039/c0sm01131b

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Facile one-pot synthesis of polymer-phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy. / Nakatsuka, Matthew A.; Lee, Joo Hye; Nakayama, Emi; Hung, Albert M.; Hsu, Mark J.; Mattrey, Robert F.; Esener, Sadik C.; Cha, Jennifer N.; Goodwin, Andrew P.

In: Soft Matter, Vol. 7, No. 5, 07.03.2011, p. 1656-1659.

Research output: Contribution to journal › Article › peer-review

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