Facile one-pot synthesis of polymer-phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy

Matthew A. Nakatsuka; Joo Hye Lee; Emi Nakayama; Albert M. Hung; Mark J. Hsu; Robert F. Mattrey; Sadik C. Esener; Jennifer N. Cha; Andrew P. Goodwin

doi:10.1039/c0sm01131b

Facile one-pot synthesis of polymer-phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy

Matthew A. Nakatsuka, Joo Hye Lee, Emi Nakayama, Albert M. Hung, Mark J. Hsu, Robert F. Mattrey, Sadik C. Esener, Jennifer N. Cha, Andrew P. Goodwin

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

This paper reports the one-pot synthesis of perfluorocarbon microbubbles with crosslinked shells of poly(acrylic acid) and phospholipid that boast excellent ultrasound contrast enhancement, enhanced loading capacity, and the ability to retain or release their contents through variation in the level of ultrasound exposure.

Original language	English (US)
Pages (from-to)	1656-1659
Number of pages	4
Journal	Soft Matter
Volume	7
Issue number	5
DOIs	https://doi.org/10.1039/c0sm01131b
State	Published - Mar 7 2011
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)
Condensed Matter Physics

Access to Document

10.1039/c0sm01131b

Cite this

Facile one-pot synthesis of polymer-phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy. / Nakatsuka, Matthew A.; Lee, Joo Hye; Nakayama, Emi; Hung, Albert M.; Hsu, Mark J.; Mattrey, Robert F.; Esener, Sadik C.; Cha, Jennifer N.; Goodwin, Andrew P.

In: Soft Matter, Vol. 7, No. 5, 07.03.2011, p. 1656-1659.

Research output: Contribution to journal › Article › peer-review

@article{d23c6513200e4f57a9266a2709997183,

title = "Facile one-pot synthesis of polymer-phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy",

abstract = "This paper reports the one-pot synthesis of perfluorocarbon microbubbles with crosslinked shells of poly(acrylic acid) and phospholipid that boast excellent ultrasound contrast enhancement, enhanced loading capacity, and the ability to retain or release their contents through variation in the level of ultrasound exposure.",

author = "Nakatsuka, {Matthew A.} and Lee, {Joo Hye} and Emi Nakayama and Hung, {Albert M.} and Hsu, {Mark J.} and Mattrey, {Robert F.} and Esener, {Sadik C.} and Cha, {Jennifer N.} and Goodwin, {Andrew P.}",

year = "2011",

month = mar,

day = "7",

doi = "10.1039/c0sm01131b",

language = "English (US)",

volume = "7",

pages = "1656--1659",

journal = "Soft Matter",

issn = "1744-683X",

publisher = "Royal Society of Chemistry",

number = "5",

}

TY - JOUR

T1 - Facile one-pot synthesis of polymer-phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy

AU - Nakatsuka, Matthew A.

AU - Lee, Joo Hye

AU - Nakayama, Emi

AU - Hung, Albert M.

AU - Hsu, Mark J.

AU - Mattrey, Robert F.

AU - Esener, Sadik C.

AU - Cha, Jennifer N.

AU - Goodwin, Andrew P.

PY - 2011/3/7

Y1 - 2011/3/7

N2 - This paper reports the one-pot synthesis of perfluorocarbon microbubbles with crosslinked shells of poly(acrylic acid) and phospholipid that boast excellent ultrasound contrast enhancement, enhanced loading capacity, and the ability to retain or release their contents through variation in the level of ultrasound exposure.

AB - This paper reports the one-pot synthesis of perfluorocarbon microbubbles with crosslinked shells of poly(acrylic acid) and phospholipid that boast excellent ultrasound contrast enhancement, enhanced loading capacity, and the ability to retain or release their contents through variation in the level of ultrasound exposure.

UR - http://www.scopus.com/inward/record.url?scp=79951930448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951930448&partnerID=8YFLogxK

U2 - 10.1039/c0sm01131b

DO - 10.1039/c0sm01131b

M3 - Article

AN - SCOPUS:79951930448

VL - 7

SP - 1656

EP - 1659

JO - Soft Matter

JF - Soft Matter

SN - 1744-683X

IS - 5

ER -

Facile one-pot synthesis of polymer-phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this