Fabrication of a flexible amperometric glucose sensor using additive processes

Xiaosong Du, Christopher J. Durgan, David J. Matthews, Joshua R. Motley, Xuebin Tan, Kovit Pholsena, Líney Árnadoóttir, Jessica R. Castle, Peter G. Jacobs, Robert S. Cargill, W. Kenneth Ward, John F. Conley, Gregory S. Herman

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

This study details the use of printing and other additive processes to fabricate a novel amperometric glucose sensor. The sensor was fabricated using a Au coated 12.7 μm thick polyimide substrate as a starting material, where micro-contact printing, electrochemical plating, chloridization, electrohydrodynamic jet (e-jet) printing, and spin coating were used to pattern, deposit, chloridize, print, and coat functional materials, respectively. We have found that e-jet printing was effective for the deposition and patterning of glucose oxidase inks with lateral feature sizes between ∼5 to 1000 μm in width, and that the glucose oxidase was still active after printing. The thickness of the permselective layer was optimized to obtain a linear response for glucose concentrations up to 32 mM and no response to acetaminophen, a common interfering compound, was observed. The use of such thin polyimide substrates allow wrapping of the sensors around catheters with high radius of curvature ∼250 μm, where additive and microfabrication methods may allow significant cost reductions.

Original languageEnglish (US)
Pages (from-to)P3069-P3074
JournalECS Journal of Solid State Science and Technology
Volume4
Issue number4
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

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    Du, X., Durgan, C. J., Matthews, D. J., Motley, J. R., Tan, X., Pholsena, K., Árnadoóttir, L., Castle, J. R., Jacobs, P. G., Cargill, R. S., Ward, W. K., Conley, J. F., & Herman, G. S. (2015). Fabrication of a flexible amperometric glucose sensor using additive processes. ECS Journal of Solid State Science and Technology, 4(4), P3069-P3074. https://doi.org/10.1149/2.0101504jss