TY - JOUR
T1 - Fabrication of a flexible amperometric glucose sensor using additive processes
AU - Du, Xiaosong
AU - Durgan, Christopher J.
AU - Matthews, David J.
AU - Motley, Joshua R.
AU - Tan, Xuebin
AU - Pholsena, Kovit
AU - Árnadoóttir, Líney
AU - Castle, Jessica R.
AU - Jacobs, Peter G.
AU - Cargill, Robert S.
AU - Ward, W. Kenneth
AU - Conley, John F.
AU - Herman, Gregory S.
N1 - Publisher Copyright:
© 2015 The Electrochemical Society.
PY - 2015
Y1 - 2015
N2 - This study details the use of printing and other additive processes to fabricate a novel amperometric glucose sensor. The sensor was fabricated using a Au coated 12.7 μm thick polyimide substrate as a starting material, where micro-contact printing, electrochemical plating, chloridization, electrohydrodynamic jet (e-jet) printing, and spin coating were used to pattern, deposit, chloridize, print, and coat functional materials, respectively. We have found that e-jet printing was effective for the deposition and patterning of glucose oxidase inks with lateral feature sizes between ∼5 to 1000 μm in width, and that the glucose oxidase was still active after printing. The thickness of the permselective layer was optimized to obtain a linear response for glucose concentrations up to 32 mM and no response to acetaminophen, a common interfering compound, was observed. The use of such thin polyimide substrates allow wrapping of the sensors around catheters with high radius of curvature ∼250 μm, where additive and microfabrication methods may allow significant cost reductions.
AB - This study details the use of printing and other additive processes to fabricate a novel amperometric glucose sensor. The sensor was fabricated using a Au coated 12.7 μm thick polyimide substrate as a starting material, where micro-contact printing, electrochemical plating, chloridization, electrohydrodynamic jet (e-jet) printing, and spin coating were used to pattern, deposit, chloridize, print, and coat functional materials, respectively. We have found that e-jet printing was effective for the deposition and patterning of glucose oxidase inks with lateral feature sizes between ∼5 to 1000 μm in width, and that the glucose oxidase was still active after printing. The thickness of the permselective layer was optimized to obtain a linear response for glucose concentrations up to 32 mM and no response to acetaminophen, a common interfering compound, was observed. The use of such thin polyimide substrates allow wrapping of the sensors around catheters with high radius of curvature ∼250 μm, where additive and microfabrication methods may allow significant cost reductions.
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U2 - 10.1149/2.0101504jss
DO - 10.1149/2.0101504jss
M3 - Article
AN - SCOPUS:84925004316
SN - 2162-8769
VL - 4
SP - P3069-P3074
JO - ECS Journal of Solid State Science and Technology
JF - ECS Journal of Solid State Science and Technology
IS - 4
ER -