Eye-of-the-Tiger Sign

S. J. Hayflick

doi:10.1016/B978-0-12-374105-9.00122-2

Eye-of-the-Tiger Sign

S. J. Hayflick

Molecular and Medical Genetics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The eye-of-the-tiger sign describes the magnetic resonance imaging (MRI) changes seen in pantothenate kinase-associated neurodegeneration (PKAN) on T₂-weighted study. The specific changes are hypointense signal in globus pallidus with a region of central or anteromedial hyperintensity. This sign is virtually pathognomic for PKAN. The hypointense region represents high tissue iron and the hyperintense region edema.

Original language	English (US)
Title of host publication	Encyclopedia of Movement Disorders
Publisher	Elsevier Inc.
Pages	471-472
Number of pages	2
ISBN (Electronic)	9780123741059
ISBN (Print)	9780123741011
DOIs	https://doi.org/10.1016/B978-0-12-374105-9.00122-2
State	Published - Jan 1 2010

Keywords

Basal ganglia
Globus pallidus
Hallervorden-Spatz syndrome
PANK2
Pantothenate kinase-associated neurodegeneration
T-weighted MRI

ASJC Scopus subject areas

General Medicine
General Neuroscience

Access to Document

10.1016/B978-0-12-374105-9.00122-2

Cite this

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abstract = "The eye-of-the-tiger sign describes the magnetic resonance imaging (MRI) changes seen in pantothenate kinase-associated neurodegeneration (PKAN) on T2-weighted study. The specific changes are hypointense signal in globus pallidus with a region of central or anteromedial hyperintensity. This sign is virtually pathognomic for PKAN. The hypointense region represents high tissue iron and the hyperintense region edema.",

keywords = "Basal ganglia, Globus pallidus, Hallervorden-Spatz syndrome, PANK2, Pantothenate kinase-associated neurodegeneration, T-weighted MRI",

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AB - The eye-of-the-tiger sign describes the magnetic resonance imaging (MRI) changes seen in pantothenate kinase-associated neurodegeneration (PKAN) on T2-weighted study. The specific changes are hypointense signal in globus pallidus with a region of central or anteromedial hyperintensity. This sign is virtually pathognomic for PKAN. The hypointense region represents high tissue iron and the hyperintense region edema.

KW - Basal ganglia

KW - Globus pallidus

KW - Hallervorden-Spatz syndrome

KW - PANK2

KW - Pantothenate kinase-associated neurodegeneration

KW - T-weighted MRI

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DO - 10.1016/B978-0-12-374105-9.00122-2

M3 - Chapter

AN - SCOPUS:85069854076

SN - 9780123741011

SP - 471

EP - 472

BT - Encyclopedia of Movement Disorders

PB - Elsevier Inc.

ER -

Eye-of-the-Tiger Sign

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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