Eye malformations in rats: Induction by prenatal exposure to nickel carbonyl

F. William Sunderman, Patricia R. Allpass, John M. Mitchell, Randall C. Baselt, Daniel Albert

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.

Original languageEnglish (US)
Pages (from-to)550-553
Number of pages4
JournalScience
Volume203
Issue number4380
StatePublished - Jan 1 1979
Externally publishedYes

Fingerprint

Anophthalmos
Microphthalmos
Inhalation
Pregnancy
Incidence
nickel carbonyl

ASJC Scopus subject areas

  • General

Cite this

William Sunderman, F., Allpass, P. R., Mitchell, J. M., Baselt, R. C., & Albert, D. (1979). Eye malformations in rats: Induction by prenatal exposure to nickel carbonyl. Science, 203(4380), 550-553.

Eye malformations in rats : Induction by prenatal exposure to nickel carbonyl. / William Sunderman, F.; Allpass, Patricia R.; Mitchell, John M.; Baselt, Randall C.; Albert, Daniel.

In: Science, Vol. 203, No. 4380, 01.01.1979, p. 550-553.

Research output: Contribution to journalArticle

William Sunderman, F, Allpass, PR, Mitchell, JM, Baselt, RC & Albert, D 1979, 'Eye malformations in rats: Induction by prenatal exposure to nickel carbonyl', Science, vol. 203, no. 4380, pp. 550-553.
William Sunderman F, Allpass PR, Mitchell JM, Baselt RC, Albert D. Eye malformations in rats: Induction by prenatal exposure to nickel carbonyl. Science. 1979 Jan 1;203(4380):550-553.
William Sunderman, F. ; Allpass, Patricia R. ; Mitchell, John M. ; Baselt, Randall C. ; Albert, Daniel. / Eye malformations in rats : Induction by prenatal exposure to nickel carbonyl. In: Science. 1979 ; Vol. 203, No. 4380. pp. 550-553.
@article{96e004734699402e8f5d95cc680f4686,
title = "Eye malformations in rats: Induction by prenatal exposure to nickel carbonyl",
abstract = "Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.",
author = "{William Sunderman}, F. and Allpass, {Patricia R.} and Mitchell, {John M.} and Baselt, {Randall C.} and Daniel Albert",
year = "1979",
month = "1",
day = "1",
language = "English (US)",
volume = "203",
pages = "550--553",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4380",

}

TY - JOUR

T1 - Eye malformations in rats

T2 - Induction by prenatal exposure to nickel carbonyl

AU - William Sunderman, F.

AU - Allpass, Patricia R.

AU - Mitchell, John M.

AU - Baselt, Randall C.

AU - Albert, Daniel

PY - 1979/1/1

Y1 - 1979/1/1

N2 - Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.

AB - Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.

UR - http://www.scopus.com/inward/record.url?scp=0018750621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018750621&partnerID=8YFLogxK

M3 - Article

C2 - 104388

AN - SCOPUS:0018750621

VL - 203

SP - 550

EP - 553

JO - Science

JF - Science

SN - 0036-8075

IS - 4380

ER -