Eye malformations in rats: Induction by prenatal exposure to nickel carbonyl

F. William Sunderman, Patricia R. Allpass, John M. Mitchell, Randall C. Baselt, Daniel M. Albert

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.

Original languageEnglish (US)
Pages (from-to)550-553
Number of pages4
JournalScience
Volume203
Issue number4380
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Eye malformations in rats: Induction by prenatal exposure to nickel carbonyl'. Together they form a unique fingerprint.

  • Cite this

    William Sunderman, F., Allpass, P. R., Mitchell, J. M., Baselt, R. C., & Albert, D. M. (1979). Eye malformations in rats: Induction by prenatal exposure to nickel carbonyl. Science, 203(4380), 550-553.