Extrinsic regulators of epithelial tumor progression

Metalloproteinases

Gabriele Bergers, Lisa Coussens

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Extracellular metal-dependent proteinases regulate cell behavior by remodeling stromal and cell surface proteins, thereby influencing cell recruitment, cell shape, motility, proliferation, survival, genomic (in)stability, and differentiation. In recent years, the importance of proteinase-induced signaling has been underscored by evidence that altered regulation of cell-extracellular matrix and cell-cell interactions by proteinases can contribute, in a causal manner, to neoplastic progression.

Original languageEnglish (US)
Pages (from-to)120-127
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume10
Issue number1
DOIs
StatePublished - Feb 1 2000
Externally publishedYes

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Metalloproteases
Peptide Hydrolases
Neoplasms
Cell Shape
Genomic Instability
Stromal Cells
Cell Communication
Cell Movement
Extracellular Matrix
Membrane Proteins
Metals

ASJC Scopus subject areas

  • Genetics

Cite this

Extrinsic regulators of epithelial tumor progression : Metalloproteinases. / Bergers, Gabriele; Coussens, Lisa.

In: Current Opinion in Genetics and Development, Vol. 10, No. 1, 01.02.2000, p. 120-127.

Research output: Contribution to journalArticle

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