Extracorporeal photopheresis in chronic graft-versus-host diseas

F. M. Foss, G. Gorgun, K. B. Miller

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Despite significant advances in stem cell manipulation and post-transplant immunosuppression, chronic graft-versus-host disease (cGVHD) remains a cause of major long-term morbidity in survivors of allogeneic stem cell transplantation. Extracorporeal photopheresis (ECP) is a novel therapeutic intervention which has demonstrated efficacy in patients with refractory acute and chronic GVHD. Clinical responses have been reported in skin and visceral GVHD. While the long-term immunomodulatory effects of ECP in cGVHD are unknown, recent studies of patients undergoing a 6- to 12-month course of ECP treatment demonstrated an attenuation of Th1-mediated cytokine secretion by activated T-helper cells, a shift in the DC1/DC2 ratio favoring plasmacytoid rather than monocytoid dendritic cell profiles, and a decrease in antigen responsiveness by dendritic cells. The implications of these immunomodulatory effects of ECP on pathogenesis and clinical outcome remains a fertile area for future research.

Original languageEnglish (US)
Pages (from-to)719-725
Number of pages7
JournalBone marrow transplantation
Volume29
Issue number9
DOIs
StatePublished - Jan 1 2002

Keywords

  • Allogeneic BMT
  • Dendritic cells
  • Extracorporeal photopheresis
  • Graft-versus-host disease
  • T cell subsets

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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