Extracellular vesicles in the hematopoietic microenvironment

John T. Butler, Sherif Abdelhamed, Peter Kurre

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Self-renewal and differentiation are defining characteristics of hematopoietic stem and progenitor cells, and their balanced regulation is central to lifelong function of both blood and immune systems. In addition to cell-intrinsic programs, hematopoietic stem and progenitor cell fate decisions are subject to extrinsic cues from within the bone marrow microenvironment and systemically. Yet, many of the paracrine and endocrine mediators that shape hematopoietic function remain to be discovered. Extracellular vesicles serve as evolutionarily conserved, constitutive regulators of cell and tissue homeostasis, with several recent reports supporting a role for extracellular vesicles in the regulation of hematopoiesis. We review the physiological and pathophysiological effects that extracellular vesicles have on bone marrow compartmental function while highlighting progress in understanding vesicle biogenesis, cargo incorporation, differential uptake, and downstream effects of vesicle internalization. This review also touches on the role of extracellular vesicles in hematopoietic stem and progenitor cell fate regulation and recent advances in therapeutic and diagnostic applications of extracellular vesicles in hematologic disorders.

Original languageEnglish (US)
Pages (from-to)382-394
Number of pages13
JournalHaematologica
Volume103
Issue number3
DOIs
StatePublished - Feb 28 2018

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Hematopoietic Stem Cells
Bone Marrow
Hematopoiesis
Cues
Extracellular Vesicles
Immune System
Homeostasis

ASJC Scopus subject areas

  • Hematology

Cite this

Extracellular vesicles in the hematopoietic microenvironment. / Butler, John T.; Abdelhamed, Sherif; Kurre, Peter.

In: Haematologica, Vol. 103, No. 3, 28.02.2018, p. 382-394.

Research output: Contribution to journalReview article

Butler, John T. ; Abdelhamed, Sherif ; Kurre, Peter. / Extracellular vesicles in the hematopoietic microenvironment. In: Haematologica. 2018 ; Vol. 103, No. 3. pp. 382-394.
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