Extracellular recording from the guinea-pig myenteric plexus and the action of morphine

R. Alan North, John T. Williams

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Extracellular recordings were made with glass suction electrodes from neurons in isolated ganglia of the myenteric plexus of the guinea-pig ileum. The activity recorded was considered to arise in neuronal somata as a consequence of the mechanical contact with the recording electrode. The spike activity was depressed by normorphine (10 nM-1 μM) and this action was prevented by low concentrations of naloxone. Morphine remained effective in solutions which contained 1 or 12 mM K+. The findings support other evidence that morphine acts by hyperpolarizing the soma membrane of myenteric neurons, but do not elucidate the ionic mechanism of the effect.

Original languageEnglish (US)
Pages (from-to)23-33
Number of pages11
JournalEuropean Journal of Pharmacology
Volume45
Issue number1
DOIs
StatePublished - Sep 1 1977

Keywords

  • Electrophysiology
  • Morphine
  • Myenteric plexus
  • Naloxone

ASJC Scopus subject areas

  • Pharmacology

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