Abstract
Extracellular recordings were made with glass suction electrodes from neurons in isolated ganglia of the myenteric plexus of the guinea-pig ileum. The activity recorded was considered to arise in neuronal somata as a consequence of the mechanical contact with the recording electrode. The spike activity was depressed by normorphine (10 nM-1 μM) and this action was prevented by low concentrations of naloxone. Morphine remained effective in solutions which contained 1 or 12 mM K+. The findings support other evidence that morphine acts by hyperpolarizing the soma membrane of myenteric neurons, but do not elucidate the ionic mechanism of the effect.
Original language | English (US) |
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Pages (from-to) | 23-33 |
Number of pages | 11 |
Journal | European Journal of Pharmacology |
Volume | 45 |
Issue number | 1 |
DOIs | |
State | Published - Sep 1 1977 |
Externally published | Yes |
Keywords
- Electrophysiology
- Morphine
- Myenteric plexus
- Naloxone
ASJC Scopus subject areas
- Pharmacology