Extraarticular Manifestations: Uveitis, Colitis, Psoriasis

Sonam Kiwalkar, James T. Rosenbaum, Sergio Schwartzman, Jan Peter Dutz, Filip Van Den Bosch

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Extraarticular manifestations (EAMs) associated with axial spondyloarthritis (axSpA) include conditions involving the skin, eye, gastrointestinal, and cardiorespiratory systems. Epidemiologic studies report their prevalence to be higher in patients with axSpA, as compared with the general population: acute anterior uveitis in 10%-40%, inflammatory bowel disease in 5%-10%, and psoriasis in 5%-10% of axSpA patients. They have a major impact on the management of axSpA and require a multispecialty approach. Moreover, their presence increases the disease burden on patients and society. Better knowledge of critical pathogenic pathways of axSpA and its EAMs could pave the road for future therapeutic approaches.

Original languageEnglish (US)
Title of host publicationAxial Spondyloarthritis
PublisherElsevier
Pages157-182
Number of pages26
ISBN (Electronic)9780323568005
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • Colitis
  • HLA-B27
  • Inflammatory bowel diseases
  • Psoriasis
  • Tumor necrosis factor inhibitors
  • Uveitis

ASJC Scopus subject areas

  • Medicine(all)

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