Extra-hypothalamic dopamine is not involved in the effects of hyperprolactinemia on male copulatory behavior

P. C. Doherty; S. J. Lane; K. A. Pfeil; W. W. Morgan; A. Bartke; M. S. Smith

doi:10.1016/0031-9384(89)90094-2

Extra-hypothalamic dopamine is not involved in the effects of hyperprolactinemia on male copulatory behavior

P. C. Doherty, S. J. Lane, K. A. Pfeil, W. W. Morgan, A. Bartke, M. S. Smith

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Experiments were performed to determine if the inhibition of copulatory behavior observed in male rats with chronically elevated serum prolactin levels (hyperprolactinemia) is associated with changes in central dopaminergic function in the nigrostriatal and mesolimbic systems. Chronic hyperprolactinemia, induced by ectopic pituitary grafts, inhibited sexual activity but was not associated with changes in locomotor activity, stereotyped behavior in response to various doses of apomorphine, or ³H-spiroperidol binding to striatal homogenates. However, open-field defecation was reduced in the pituitary grafted animals. The results of the present study show that changes in nigrostriatal dopamine receptor sensitivity do not contribute to the inhibition of sexual behavior in hyperprolactinemic male rats. In addition, these results also demonstrate that the effects of hyperprolactinemia are relatively specific to copulatory behavior and appear not to involve general behavioral suppression.

Original language	English (US)
Pages (from-to)	1101-1105
Number of pages	5
Journal	Physiology and Behavior
Volume	45
Issue number	6
DOIs	https://doi.org/10.1016/0031-9384(89)90094-2
State	Published - Jun 1989
Externally published	Yes

Keywords

Copulatory behavior
Defecation
Dopamine receptors
Hyperprolactinemia
Locomotor activity
Stereotypy

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/0031-9384(89)90094-2

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title = "Extra-hypothalamic dopamine is not involved in the effects of hyperprolactinemia on male copulatory behavior",

abstract = "Experiments were performed to determine if the inhibition of copulatory behavior observed in male rats with chronically elevated serum prolactin levels (hyperprolactinemia) is associated with changes in central dopaminergic function in the nigrostriatal and mesolimbic systems. Chronic hyperprolactinemia, induced by ectopic pituitary grafts, inhibited sexual activity but was not associated with changes in locomotor activity, stereotyped behavior in response to various doses of apomorphine, or 3H-spiroperidol binding to striatal homogenates. However, open-field defecation was reduced in the pituitary grafted animals. The results of the present study show that changes in nigrostriatal dopamine receptor sensitivity do not contribute to the inhibition of sexual behavior in hyperprolactinemic male rats. In addition, these results also demonstrate that the effects of hyperprolactinemia are relatively specific to copulatory behavior and appear not to involve general behavioral suppression.",

keywords = "Copulatory behavior, Defecation, Dopamine receptors, Hyperprolactinemia, Locomotor activity, Stereotypy",

author = "Doherty, {P. C.} and Lane, {S. J.} and Pfeil, {K. A.} and Morgan, {W. W.} and A. Bartke and Smith, {M. S.}",

note = "Funding Information: ACKNOWLEDGEMENTS The authors are grateful to Gretta Small and the NEOUCOM Word Processing Center for their assistance m preparing this manuscript, to Dr Richard W Steger for his advice and help in performing these studies, and to Neva Andor for her excellent techmcal assistance This work was supported by NIH grants P30 and HD 10202 (Bloassay Core) and HD 12671 and DA 00755",

year = "1989",

month = jun,

doi = "10.1016/0031-9384(89)90094-2",

language = "English (US)",

volume = "45",

pages = "1101--1105",

journal = "Physiology and Behavior",

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T1 - Extra-hypothalamic dopamine is not involved in the effects of hyperprolactinemia on male copulatory behavior

AU - Doherty, P. C.

AU - Lane, S. J.

AU - Pfeil, K. A.

AU - Morgan, W. W.

AU - Bartke, A.

AU - Smith, M. S.

N1 - Funding Information: ACKNOWLEDGEMENTS The authors are grateful to Gretta Small and the NEOUCOM Word Processing Center for their assistance m preparing this manuscript, to Dr Richard W Steger for his advice and help in performing these studies, and to Neva Andor for her excellent techmcal assistance This work was supported by NIH grants P30 and HD 10202 (Bloassay Core) and HD 12671 and DA 00755

PY - 1989/6

Y1 - 1989/6

N2 - Experiments were performed to determine if the inhibition of copulatory behavior observed in male rats with chronically elevated serum prolactin levels (hyperprolactinemia) is associated with changes in central dopaminergic function in the nigrostriatal and mesolimbic systems. Chronic hyperprolactinemia, induced by ectopic pituitary grafts, inhibited sexual activity but was not associated with changes in locomotor activity, stereotyped behavior in response to various doses of apomorphine, or 3H-spiroperidol binding to striatal homogenates. However, open-field defecation was reduced in the pituitary grafted animals. The results of the present study show that changes in nigrostriatal dopamine receptor sensitivity do not contribute to the inhibition of sexual behavior in hyperprolactinemic male rats. In addition, these results also demonstrate that the effects of hyperprolactinemia are relatively specific to copulatory behavior and appear not to involve general behavioral suppression.

AB - Experiments were performed to determine if the inhibition of copulatory behavior observed in male rats with chronically elevated serum prolactin levels (hyperprolactinemia) is associated with changes in central dopaminergic function in the nigrostriatal and mesolimbic systems. Chronic hyperprolactinemia, induced by ectopic pituitary grafts, inhibited sexual activity but was not associated with changes in locomotor activity, stereotyped behavior in response to various doses of apomorphine, or 3H-spiroperidol binding to striatal homogenates. However, open-field defecation was reduced in the pituitary grafted animals. The results of the present study show that changes in nigrostriatal dopamine receptor sensitivity do not contribute to the inhibition of sexual behavior in hyperprolactinemic male rats. In addition, these results also demonstrate that the effects of hyperprolactinemia are relatively specific to copulatory behavior and appear not to involve general behavioral suppression.

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KW - Locomotor activity

KW - Stereotypy

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Extra-hypothalamic dopamine is not involved in the effects of hyperprolactinemia on male copulatory behavior

Abstract

Keywords

ASJC Scopus subject areas

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