Extinction, renewal, and spontaneous recovery of a spatial preference in the water maze

Kennon (Matt) Lattal, Michael T. Mullen, Ted Abel

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Four experiments with C57BL/6 mice investigated extinction of a spatial preference in the Morris water maze. In Experiment 1, a spatial preference was extinguished by exposing mice to the water maze in the absence of a platform but in the presence of the distal spatial cues. In Experiment 2, extinction occurred when the platform was removed from the pool, when it was presented in random locations, or when it was presented consistently in the opposite location. Contextual renewal (Experiment 3) and spontaneous recovery (Experiment 4) of spatial preferences argue against an interpretation of extinction in terms of unlearning and instead suggest that extinction in the water maze, like extinction in Pavlovian conditioning, suppresses the original association. Implications of these findings for theories of spatial learning and hippocampal function are discussed.

Original languageEnglish (US)
Pages (from-to)1017-1028
Number of pages12
JournalBehavioral Neuroscience
Volume117
Issue number5
DOIs
StatePublished - Oct 2003
Externally publishedYes

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Water
Inbred C57BL Mouse
Cues
Psychological Extinction
Spatial Learning
Conditioning (Psychology)

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Extinction, renewal, and spontaneous recovery of a spatial preference in the water maze. / Lattal, Kennon (Matt); Mullen, Michael T.; Abel, Ted.

In: Behavioral Neuroscience, Vol. 117, No. 5, 10.2003, p. 1017-1028.

Research output: Contribution to journalArticle

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