Expression of Transforming Growth Factor β1 in Patients with and without Previous Abdominal Surgery

Kristina G. Hobson, Michelle DeWing, Hung S. Ho, Bruce M. Wolfe, Kiho Cho, David G. Greenhalgh

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Hypothesis: Transforming growth factor β1 (TGF-β1) plays an important role in the formation of adhesions after abdominal operations. Design: Prospective, observational study. Setting: University-based, tertiary referral center. Patients: Patients undergoing elective open abdominal operations were recruited and divided into 2 groups. Twenty-two patients with a history of abdominal surgery were designated as study patients, and 10 patients with no history of abdominal surgery served as controls. Interventions: Samples of normal peritoneum, peritoneal scar tissues, and serum were obtained from all patients at the time of surgery. Main Outcome Measures: Samples were assayed for total TGF-β1 expression using an enzyme-linked immunosorbent assay. Results: Scar tissues expressed significantly greater amounts of TGF-β1 (0.47 pg/μL) compared with normal peritoneal tissue from both study patients (0.29 pg/ μL; P=.03) and controls (0.17 pg/μL; P=.002). Serum TGF-β1 levels were also higher in study patients (1.71 pg/μL) compared with controls (1.22 pg/μL; P=.02). Neither adhesion nor serum TGF-β1 expression correlated with time since last operation, total number of previous operations, or severity of intra-abdominal adhesions. Conclusion: These results suggest that TGF-β1 may play an important role in human peritoneal adhesion formation.

Original languageEnglish (US)
Pages (from-to)1249-1252
Number of pages4
JournalArchives of Surgery
Volume138
Issue number11
DOIs
StatePublished - Nov 1 2003

ASJC Scopus subject areas

  • Surgery

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