Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen

G. Kraal, K. Schornagel, Philip Streeter, B. Holzmann, E. C. Butcher

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The MAdCAM-1 adhesion molecule is involved in lymphocyte homing into mucosal sites and is expressed on high endothelial venules of Peyer's patches and mesenteric lymph nodes. In the spleen, where high endothelial venules are absent, expression can be found on cells in the marginal zone between red and white pulp. By immunohistochemistry and electron microscopy it was demonstrated that in the spleen cells expressing MAdCAM-1 belong to the population of sinus-lining cells and that the expression is restricted to the sinus-lining cells closest to the lymphoid white pulp. Lymphocytes that migrate from the blood into this white pulp area will have to pass through the rim of cells expressing MAdCAM-1. A functional role for MAdCAM-1 or its lymphocyte ligand, the α4β7 integrin complex, was investigated by in vivo short-term boming experiments with anti-MAdCAM-1 and anti-α4β7 antibodies, but no direct role for this receptor-ligand interaction could be demonstrated.

Original languageEnglish (US)
Pages (from-to)763-771
Number of pages9
JournalAmerican Journal of Pathology
Volume147
Issue number3
StatePublished - 1995
Externally publishedYes

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Spleen
Venules
Lymphocytes
Ligands
Peyer's Patches
Integrins
Anti-Idiotypic Antibodies
Electron Microscopy
Lymph Nodes
Immunohistochemistry
L-selectin counter-receptors
Population

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kraal, G., Schornagel, K., Streeter, P., Holzmann, B., & Butcher, E. C. (1995). Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen. American Journal of Pathology, 147(3), 763-771.

Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen. / Kraal, G.; Schornagel, K.; Streeter, Philip; Holzmann, B.; Butcher, E. C.

In: American Journal of Pathology, Vol. 147, No. 3, 1995, p. 763-771.

Research output: Contribution to journalArticle

Kraal, G, Schornagel, K, Streeter, P, Holzmann, B & Butcher, EC 1995, 'Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen', American Journal of Pathology, vol. 147, no. 3, pp. 763-771.
Kraal G, Schornagel K, Streeter P, Holzmann B, Butcher EC. Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen. American Journal of Pathology. 1995;147(3):763-771.
Kraal, G. ; Schornagel, K. ; Streeter, Philip ; Holzmann, B. ; Butcher, E. C. / Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen. In: American Journal of Pathology. 1995 ; Vol. 147, No. 3. pp. 763-771.
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