Expression of the c-myc Protooncogene in Human Prostatic Carcinoma and Benign Prostatic Hyperplasia

William H. Fleming, Andre Hamel, Janice G. Dodd, Robert J. Matusik, Robert MacDonald, Ernest Ramsey, Norman M. Pettiarew, Brian Johnston

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Abstract

We have examined the level of c-myc transcripts in prostate tissue obtained from patients with both benign prostatic hyperplasia and adenocarcinoma of the prostate. A significantly higher level of c-myc transcripts is observed in patients with adenocarcinoma (P < 0.05). In addition, a subset of patients with adenocarcinoma had levels of c-myc transcripts 2-fold higher than the mean level for this group. These preliminary results indicate that the investigation of c-myc levels as a prognostic indicator in prostatic carcinoma is warranted.

Original languageEnglish (US)
Pages (from-to)1535-1538
Number of pages4
JournalCancer Research
Volume46
Issue number3
StatePublished - Mar 1 1986

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Fleming, W. H., Hamel, A., Dodd, J. G., Matusik, R. J., MacDonald, R., Ramsey, E., Pettiarew, N. M., & Johnston, B. (1986). Expression of the c-myc Protooncogene in Human Prostatic Carcinoma and Benign Prostatic Hyperplasia. Cancer Research, 46(3), 1535-1538.