Expression of the c-fos gene in the mouse brain during the acquisition of defensive behavior habits

K. V. Anokhin, Andrey Ryabinin, K. V. Sudakov

Research output: Contribution to journalArticle

6 Scopus citations


Experimental data reported here provide evidence that marked defensive motivation in conditions of an unavoidable electrocutaneous stimulus is accompanied in mice by increases in the expression to the c-fos gene in the hippocampus and cerebral cortex. As reinforcement and learning progress and the animals become able to achieve a useful result - avoiding the electrocutaneous shock - expression of the c-fos gene in these brain structures decreases. The level of expression of the c-fos gene was found to be different in animals in which defensive behavior had different efficacies. Expression was higher in mice making large numbers of errors than in mice with few errors during acquisition of the defensive habit.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalNeuroscience and Behavioral Physiology
Issue number2
Publication statusPublished - 2001
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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