Expression of T cell receptor delta chains in benign and malignant T lineage lymphoproliferations

Louis Picker, M. B. Brenner, S. Michie, R. A. Warnke

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Recent studies in both human and murine systems have demonstrated the existence of a second CD3-associated T cell receptor (the γ δ-TCR) distinct from the αβ heterodimer associated with antigen recognition by classical T cells. Using a monoclonal antibody specific for the δ component of the human γδ-TCR, the expression of this antigen in both benign, reactive lymphoid tissues and T lineage lymphomas was studied with immunohistologic techniques. In the normal thymus, TCR-δ+ cells constituted less than 5% of the CD3+ thymocytes and were located primarily in the medulla or juxtamedullary cortex. Within the T zones of 16 histologically varied reactive peripheral lymphoid tissues, including four patients with marked predominantly paracortical hyperplasia, the authors identified from less than 1% to a maximum of 5% TCR-δ+ cells. While these results are consistent with the hypothesis that TCR-γδ+ cells comprise a small distinct subpopulation of peripheral T cells in humans, selective localization or recruitment of these cells could not be demonstrated in any of a number of tissues or reactive situations. Among 62 T lineage lymphomas, including 14 CD3+/TCR-β- cases, only two TCR-δ+ neoplasms were identified, both lymphoblastic lymphomas displaying the CD3+/CD4-/CD8- phenotype known to be associated with normal TCR-γδ+ T cells. Because the majority of CD3A+/TCR-β- lymphomas did not display TCR-δ, these results argue against the hypothesis that the high incidence of CD3/TCR-β discordance noted in T lineage lymphomas represents preferential transformation of the TCR-δ-expressing subset.

Original languageEnglish (US)
Pages (from-to)401-405
Number of pages5
JournalAmerican Journal of Pathology
Volume132
Issue number3
StatePublished - 1988
Externally publishedYes

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Antigen Receptors, T-Cell, gamma-delta
Lymphoma
Lymphoid Tissue
T-Lymphocytes
Antigens
Thymocytes
T-Cell Antigen Receptor
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thymus Gland
Hyperplasia
Monoclonal Antibodies
Phenotype
Incidence
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression of T cell receptor delta chains in benign and malignant T lineage lymphoproliferations. / Picker, Louis; Brenner, M. B.; Michie, S.; Warnke, R. A.

In: American Journal of Pathology, Vol. 132, No. 3, 1988, p. 401-405.

Research output: Contribution to journalArticle

Picker, Louis ; Brenner, M. B. ; Michie, S. ; Warnke, R. A. / Expression of T cell receptor delta chains in benign and malignant T lineage lymphoproliferations. In: American Journal of Pathology. 1988 ; Vol. 132, No. 3. pp. 401-405.
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