Expression of LFA-1 in non-Hodgkin's lymphoma

L. J. Medeiros, L. M. Weiss, Louis Picker, C. Clayberger, S. J. Horning, A. M. Krensky, R. A. Warnke

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Abstract

Lymphocyte function-associated antigen 1 (LFA-1) is a glycoprotein involved in virtually all aspects of the immune response requiring direct cell to cell contact. It has been suggested that lack of LFA-1 expression in lymphomas may represent a mechanism of escape from immunologic surveillance. We investigated the expression of LFA-1 in a series of more than 250 lymphoid neoplasms and reactive lymphoid proliferations using a frozen section immunoperoxidase technique. LFA-1 was expressed by all lymphoid populations in the reactive cases. In contrast, absence of LFA-1 alpha or beta chains was found in 44% of non-Hodgkin's lymphomas, including 50% of B-cell lymphomas. These findings suggest that loss of LFA-1 expression may be of great use in the differential diagnosis of benign versus malignant lymphoproliferations. Eighty percent of initial biopsy specimens of low-grade lymphoma exhibited LFA-1 expression, whereas only 8% of recurrent specimens retained expression of both LFA-1 subunits. However, we found no correlation between LFA-1 expression and clinical course in a series of 64 patients with diffuse large cell lymphomas.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalCancer
Volume63
Issue number2
StatePublished - 1989
Externally publishedYes

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Lymphocyte Function-Associated Antigen-1
Non-Hodgkin's Lymphoma
Immunologic Surveillance
Lymphoma, Large B-Cell, Diffuse
Frozen Sections
B-Cell Lymphoma
Immunoenzyme Techniques
Lymphoma
Glycoproteins
Differential Diagnosis
Biopsy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Medeiros, L. J., Weiss, L. M., Picker, L., Clayberger, C., Horning, S. J., Krensky, A. M., & Warnke, R. A. (1989). Expression of LFA-1 in non-Hodgkin's lymphoma. Cancer, 63(2), 255-259.

Expression of LFA-1 in non-Hodgkin's lymphoma. / Medeiros, L. J.; Weiss, L. M.; Picker, Louis; Clayberger, C.; Horning, S. J.; Krensky, A. M.; Warnke, R. A.

In: Cancer, Vol. 63, No. 2, 1989, p. 255-259.

Research output: Contribution to journalArticle

Medeiros, LJ, Weiss, LM, Picker, L, Clayberger, C, Horning, SJ, Krensky, AM & Warnke, RA 1989, 'Expression of LFA-1 in non-Hodgkin's lymphoma', Cancer, vol. 63, no. 2, pp. 255-259.
Medeiros LJ, Weiss LM, Picker L, Clayberger C, Horning SJ, Krensky AM et al. Expression of LFA-1 in non-Hodgkin's lymphoma. Cancer. 1989;63(2):255-259.
Medeiros, L. J. ; Weiss, L. M. ; Picker, Louis ; Clayberger, C. ; Horning, S. J. ; Krensky, A. M. ; Warnke, R. A. / Expression of LFA-1 in non-Hodgkin's lymphoma. In: Cancer. 1989 ; Vol. 63, No. 2. pp. 255-259.
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