Expression of glutamate receptor subunit genes during development of the mouse retina

Congxiao Zhang, Dânia E. Hammassaki-Britto, Luiz R G Britto, Robert Duvoisin

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The distribution of expression during retinal differentiation of nine AMPA and kainate glutamate receptor subunit genes was studied by in situ hybridization. Transcripts encoding all subunits were detected in the inner nuclear and ganglion cell layers of the developing mouse retina, but their time courses of expression differed. The earliest expression was detected at embryonic day 14 (E14) for GluR1, GluR4 and KA-2; all the other subunits were first detected at E16. Most subunits were expressed at higher levels during development than in the adult. This suggests they play a role in the processes of neuronal differentiation and synaptogenesis that occur during the early postnatal days in the rodent retina.

Original languageEnglish (US)
Pages (from-to)335-340
Number of pages6
JournalNeuroReport
Volume8
Issue number1
Publication statusPublished - 1997
Externally publishedYes

    Fingerprint

Keywords

  • AMPA
  • Development
  • Differentiation
  • Glutamate receptor
  • In situ hybridization
  • Kainate
  • Retina
  • Synaptogenesis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Zhang, C., Hammassaki-Britto, D. E., Britto, L. R. G., & Duvoisin, R. (1997). Expression of glutamate receptor subunit genes during development of the mouse retina. NeuroReport, 8(1), 335-340.