Expression of endogenous granzyme B in a subset of human primary breast carcinomas

S. X. Hu, S. Wang, J. P. Wang, G. B. Mills, Y. Zhou, H. J. Xu

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Granzyme B (GrB) is the prototypic member of a serine protease family primarily used by cytotoxic lymphocytes to kill target cells. We report here that, by immunohistochemical staining of paraffin-embedded tumour sections, GrB protein was unexpectedly detected in malignant cells of a subset of breast cancers and their adjacent reactive endothelial and mesenchymal cells in which endogenous retinoblastoma protein (pRB) is overexpressed. The identity of the endogenous GrB was further confirmed experimentally in RB-deficient breast carcinoma cell culture upon overexpression of ectopic pRB. Our finding extends the recent paradigm-shifting trend for a more diverse biological role of granzyme B, and might provide a rational basis for exploring its potential prognostic value in a variety of human cancers.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalBritish Journal of Cancer
Volume89
Issue number1
DOIs
StatePublished - Jul 7 2003
Externally publishedYes

Keywords

  • Breast cancer
  • Endogenous granzyme B
  • Nonimmune cells
  • Retinoblastoma tumour suppressor gene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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