Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

Shuying Liu, Makiko Umezu-Goto, Mandi Murph, Yiling Lu, Wenbin Liu, Fan Zhang, Shuangxing Yu, L. Clifton Stephens, Xiaojiang Cui, George Murrow, Kevin Coombes, William Muller, Mien Chie Hung, Charles M. Perou, Adrian V. Lee, Xianjun Fang, Gordon B. Mills

Research output: Contribution to journalArticlepeer-review

276 Scopus citations

Abstract

Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.

Original languageEnglish (US)
Pages (from-to)539-550
Number of pages12
JournalCancer Cell
Volume15
Issue number6
DOIs
StatePublished - Jun 2 2009
Externally publishedYes

Keywords

  • CELLCYCLE

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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