Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

Shuying Liu, Makiko Umezu-Goto, Mandi Murph, Yiling Lu, Wenbin Liu, Fan Zhang, Shuangxing Yu, L. Clifton Stephens, Xiaojiang Cui, George Murrow, Kevin Coombes, William Muller, Mien Chie Hung, Charles M. Perou, Adrian V. Lee, Xianjun Fang, Gordon B. Mills

    Research output: Contribution to journalArticle

    263 Scopus citations

    Abstract

    Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.

    Original languageEnglish (US)
    Pages (from-to)539-550
    Number of pages12
    JournalCancer Cell
    Volume15
    Issue number6
    DOIs
    StatePublished - Jun 2 2009

    Keywords

    • CELLCYCLE

    ASJC Scopus subject areas

    • Oncology
    • Cell Biology
    • Cancer Research

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