Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

Shuying Liu, Makiko Umezu-Goto, Mandi Murph, Yiling Lu, Wenbin Liu, Fan Zhang, Shuangxing Yu, L. Clifton Stephens, Xiaojiang Cui, George Murrow, Kevin Coombes, William Muller, Mien Chie Hung, Charles M. Perou, Adrian V. Lee, Xianjun Fang, Gordon Mills

Research output: Contribution to journalArticle

252 Citations (Scopus)

Abstract

Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.

Original languageEnglish (US)
Pages (from-to)539-550
Number of pages12
JournalCancer Cell
Volume15
Issue number6
DOIs
StatePublished - Jun 2 2009
Externally publishedYes

Fingerprint

Lysophosphatidic Acid Receptors
Carcinogenesis
Breast
Neoplasm Metastasis
Breast Neoplasms
G-Protein-Coupled Receptors
Estrogen Receptors
Transgenic Mice
Epithelium
Enzymes
Neoplasms

Keywords

  • CELLCYCLE

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases. / Liu, Shuying; Umezu-Goto, Makiko; Murph, Mandi; Lu, Yiling; Liu, Wenbin; Zhang, Fan; Yu, Shuangxing; Stephens, L. Clifton; Cui, Xiaojiang; Murrow, George; Coombes, Kevin; Muller, William; Hung, Mien Chie; Perou, Charles M.; Lee, Adrian V.; Fang, Xianjun; Mills, Gordon.

In: Cancer Cell, Vol. 15, No. 6, 02.06.2009, p. 539-550.

Research output: Contribution to journalArticle

Liu, S, Umezu-Goto, M, Murph, M, Lu, Y, Liu, W, Zhang, F, Yu, S, Stephens, LC, Cui, X, Murrow, G, Coombes, K, Muller, W, Hung, MC, Perou, CM, Lee, AV, Fang, X & Mills, G 2009, 'Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases', Cancer Cell, vol. 15, no. 6, pp. 539-550. https://doi.org/10.1016/j.ccr.2009.03.027
Liu, Shuying ; Umezu-Goto, Makiko ; Murph, Mandi ; Lu, Yiling ; Liu, Wenbin ; Zhang, Fan ; Yu, Shuangxing ; Stephens, L. Clifton ; Cui, Xiaojiang ; Murrow, George ; Coombes, Kevin ; Muller, William ; Hung, Mien Chie ; Perou, Charles M. ; Lee, Adrian V. ; Fang, Xianjun ; Mills, Gordon. / Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases. In: Cancer Cell. 2009 ; Vol. 15, No. 6. pp. 539-550.
@article{7a66ac0652554bbb97ee5121a9793cff,
title = "Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases",
abstract = "Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.",
keywords = "CELLCYCLE",
author = "Shuying Liu and Makiko Umezu-Goto and Mandi Murph and Yiling Lu and Wenbin Liu and Fan Zhang and Shuangxing Yu and Stephens, {L. Clifton} and Xiaojiang Cui and George Murrow and Kevin Coombes and William Muller and Hung, {Mien Chie} and Perou, {Charles M.} and Lee, {Adrian V.} and Xianjun Fang and Gordon Mills",
year = "2009",
month = "6",
day = "2",
doi = "10.1016/j.ccr.2009.03.027",
language = "English (US)",
volume = "15",
pages = "539--550",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

AU - Liu, Shuying

AU - Umezu-Goto, Makiko

AU - Murph, Mandi

AU - Lu, Yiling

AU - Liu, Wenbin

AU - Zhang, Fan

AU - Yu, Shuangxing

AU - Stephens, L. Clifton

AU - Cui, Xiaojiang

AU - Murrow, George

AU - Coombes, Kevin

AU - Muller, William

AU - Hung, Mien Chie

AU - Perou, Charles M.

AU - Lee, Adrian V.

AU - Fang, Xianjun

AU - Mills, Gordon

PY - 2009/6/2

Y1 - 2009/6/2

N2 - Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.

AB - Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.

KW - CELLCYCLE

UR - http://www.scopus.com/inward/record.url?scp=65649132676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65649132676&partnerID=8YFLogxK

U2 - 10.1016/j.ccr.2009.03.027

DO - 10.1016/j.ccr.2009.03.027

M3 - Article

C2 - 19477432

AN - SCOPUS:65649132676

VL - 15

SP - 539

EP - 550

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 6

ER -