Expressed sequence tags from the long arm of human chromosome 21

Pei Wen Chiang, Grzegorz Dzida, Jordan Grumet, Jan Fang Cheng, Woo Joo Song, Eric Crombez, Margaret L. Vankeuren, David M. Kurnit

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We isolated expressed sequence tags (ESTs) on the long arm of chromosome 21. The ESTs were mapped by PCR using a monochromosomal somatic-cell mapping panel. Of a total of 55 cDNAs, 30 mapped back uniquely to chromosome 21, 7 mapped back to other chromosomes including chromosome 21, 8 mapped back to chromosomes other than 21, and 10 could not be assigned using this methodology. The 30 chromosome 21-specific markers so isolated represent useful EST markers. A rapid PCR-based method was used to delineate the expression pattern of these 30 pairs in different tissues.

Original languageEnglish (US)
Pages (from-to)383-389
Number of pages7
JournalGenomics
Volume29
Issue number2
DOIs
StatePublished - Sep 1995

ASJC Scopus subject areas

  • Genetics

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    Chiang, P. W., Dzida, G., Grumet, J., Cheng, J. F., Song, W. J., Crombez, E., Vankeuren, M. L., & Kurnit, D. M. (1995). Expressed sequence tags from the long arm of human chromosome 21. Genomics, 29(2), 383-389. https://doi.org/10.1006/geno.1995.9991