Exposure to AN aeroallergen AS a possible precipitating factor in respiratory arrest in young patients with asthma

Mark O'Hollaren, John W. Yunginger, Kenneth P. Offord, Michael J. Somers, Edward J. O'Connell, David J. Ballard, Martin I. Sachs

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Abstract

Background. Exposure to airborne spores of the common mold Alternaria alternate has been implicated in asthma attacks. Such exposure is particularly frequent in the Midwest during the summer and fall months. To determine the role of A. alternata in triggering severe asthma attacks, we investigated the cases of 11 patients with asthma who had sudden respiratory arrest and determined the frequency of sensitivity to this allergen in these patients. Methods. The 11 patients (age range, 11 to 25 years) with initial episodes of respiratory arrest, which was fatal in 2 patients, were identified in the course of their care in our pediatric and adult clinical allergy practice and by a retrospective review of all Mayo Clinic records of patients with severe asthma cared for between 1980 and 1989. Skin-test reactivity to A. alternata and levels of IgE antibody against this mold in the 11 patients were compared with those in 99 matched controls with asthma who had no history of respiratory arrest. Results. All the patients came from the upper Midwest, and the episodes of respiratory arrest occurred in the summer or early fall. Ten of the 11 patients with asthma who had respiratory arrest (91 percent) had positive skin-puncture tests for sensitivity to alternaria, as compared with 31 percent of the controls (P

Original languageEnglish (US)
Pages (from-to)359-363
Number of pages5
JournalNew England Journal of Medicine
Volume324
Issue number6
StatePublished - Feb 7 1991
Externally publishedYes

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Precipitating Factors
Asthma
Alternaria
Skin Tests
Fungi
Spores
Punctures
Allergens
Immunoglobulin E
Hypersensitivity
Pediatrics
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

O'Hollaren, M., Yunginger, J. W., Offord, K. P., Somers, M. J., O'Connell, E. J., Ballard, D. J., & Sachs, M. I. (1991). Exposure to AN aeroallergen AS a possible precipitating factor in respiratory arrest in young patients with asthma. New England Journal of Medicine, 324(6), 359-363.

Exposure to AN aeroallergen AS a possible precipitating factor in respiratory arrest in young patients with asthma. / O'Hollaren, Mark; Yunginger, John W.; Offord, Kenneth P.; Somers, Michael J.; O'Connell, Edward J.; Ballard, David J.; Sachs, Martin I.

In: New England Journal of Medicine, Vol. 324, No. 6, 07.02.1991, p. 359-363.

Research output: Contribution to journalArticle

O'Hollaren, M, Yunginger, JW, Offord, KP, Somers, MJ, O'Connell, EJ, Ballard, DJ & Sachs, MI 1991, 'Exposure to AN aeroallergen AS a possible precipitating factor in respiratory arrest in young patients with asthma', New England Journal of Medicine, vol. 324, no. 6, pp. 359-363.
O'Hollaren, Mark ; Yunginger, John W. ; Offord, Kenneth P. ; Somers, Michael J. ; O'Connell, Edward J. ; Ballard, David J. ; Sachs, Martin I. / Exposure to AN aeroallergen AS a possible precipitating factor in respiratory arrest in young patients with asthma. In: New England Journal of Medicine. 1991 ; Vol. 324, No. 6. pp. 359-363.
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