Exploring the relationship between β-adrenergic receptor kinase-1 and physical symptoms in heart failure

Quin Denfeld, James Mudd, Wohaib Hasan, Jill Gelow, Shirin O. Hiatt, Kerri Winters-Stone, Christopher Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The relationship between physical heart failure (HF) symptoms and pathophysiological mechanisms is unclear. Objective: To quantify the relationship between plasma β-adrenergic receptor kinase-1 (βARK1) and physical symptoms among adults with HF. Methods: We performed a secondary analysis of data collected from two studies of adults with HF. Plasma βARK1 was quantified using an enzyme-linked immunosorbent assay. Physical symptoms were measured with the HF Somatic Perception Scale (HFSPS). Generalized linear modeling was used to quantify the relationship between βARK1 and HFSPS scores. Results: The average age (n = 94) was 54.5 ± 13.1 years, 76.6% were male, and a majority (83.0%) had Class III or IV HF. βARK1 was significantly associated with HFSPS scores (β = 0.22 ± 0.10, p = 0.038), adjusting for other predictors of physical symptoms (model R2 = 0.250, F(7, 70) = 3.34, p = 0.004). Conclusions: Higher βARK1 is associated with worse physical HF symptoms, pinpointing a potential pathophysiologic underpinning.

Original languageEnglish (US)
JournalHeart and Lung
DOIs
StateAccepted/In press - Jan 1 2018

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Adrenergic Receptors
Phosphotransferases
Heart Failure
Enzyme-Linked Immunosorbent Assay

Keywords

  • Beta-adrenergic receptor kinases
  • Biomarkers
  • G protein-coupled receptor kinase-2
  • Heart failure
  • Symptom

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Exploring the relationship between β-adrenergic receptor kinase-1 and physical symptoms in heart failure. / Denfeld, Quin; Mudd, James; Hasan, Wohaib; Gelow, Jill; Hiatt, Shirin O.; Winters-Stone, Kerri; Lee, Christopher.

In: Heart and Lung, 01.01.2018.

Research output: Contribution to journalArticle

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AU - Winters-Stone, Kerri

AU - Lee, Christopher

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KW - Symptom

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