Exploration of signals of positive selection derived from genotype-based human genome scans using re-sequencing data

Min Hu, Qasim Ayub, José Afonso Guerra-Assunção, Quan Long, Zemin Ning, Ni Huang, Irene Gallego Romero, Lira Mamanova, Pelin Akan, Xin Liu, Alison J. Coffey, Daniel J. Turner, Harold Swerdlow, John Burton, Michael A. Quail, Don Conrad, Anton J. Enright, Chris Tyler-Smith, Yali Xue

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We have investigated whether regions of the genome showing signs of positive selection in scans based on haplotype structure also show evidence of positive selection when sequence-based tests are applied, whether the target of selection can be localized more precisely, and whether such extra evidence can lead to increased biological insights. We used two tools: simulations under neutrality or selection, and experimental investigation of two regions identified by the HapMap2 project as putatively selected in human populations. Simulations suggested that neutral and selected regions should be readily distinguished and that it should be possible to localize the selected variant to within 40 kb at least half of the time. Re-sequencing of two ∼300 kb regions (chr4:158Mb and chr10:22Mb) lacking known targets of selection in HapMap CHB individuals provided strong evidence for positive selection within each and suggested the micro-RNA gene hsa-miR-548c as the best candidate target in one region, and changes in regulation of the sperm protein gene SPAG6 in the other.

Original languageEnglish (US)
Pages (from-to)665-674
Number of pages10
JournalHuman genetics
Volume131
Issue number5
DOIs
StatePublished - May 1 2012
Externally publishedYes

Fingerprint

HapMap Project
Human Genome
MicroRNAs
Haplotypes
Spermatozoa
Genotype
Genome
Population
Genes
Proteins

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Hu, M., Ayub, Q., Guerra-Assunção, J. A., Long, Q., Ning, Z., Huang, N., ... Xue, Y. (2012). Exploration of signals of positive selection derived from genotype-based human genome scans using re-sequencing data. Human genetics, 131(5), 665-674. https://doi.org/10.1007/s00439-011-1111-9

Exploration of signals of positive selection derived from genotype-based human genome scans using re-sequencing data. / Hu, Min; Ayub, Qasim; Guerra-Assunção, José Afonso; Long, Quan; Ning, Zemin; Huang, Ni; Romero, Irene Gallego; Mamanova, Lira; Akan, Pelin; Liu, Xin; Coffey, Alison J.; Turner, Daniel J.; Swerdlow, Harold; Burton, John; Quail, Michael A.; Conrad, Don; Enright, Anton J.; Tyler-Smith, Chris; Xue, Yali.

In: Human genetics, Vol. 131, No. 5, 01.05.2012, p. 665-674.

Research output: Contribution to journalArticle

Hu, M, Ayub, Q, Guerra-Assunção, JA, Long, Q, Ning, Z, Huang, N, Romero, IG, Mamanova, L, Akan, P, Liu, X, Coffey, AJ, Turner, DJ, Swerdlow, H, Burton, J, Quail, MA, Conrad, D, Enright, AJ, Tyler-Smith, C & Xue, Y 2012, 'Exploration of signals of positive selection derived from genotype-based human genome scans using re-sequencing data', Human genetics, vol. 131, no. 5, pp. 665-674. https://doi.org/10.1007/s00439-011-1111-9
Hu, Min ; Ayub, Qasim ; Guerra-Assunção, José Afonso ; Long, Quan ; Ning, Zemin ; Huang, Ni ; Romero, Irene Gallego ; Mamanova, Lira ; Akan, Pelin ; Liu, Xin ; Coffey, Alison J. ; Turner, Daniel J. ; Swerdlow, Harold ; Burton, John ; Quail, Michael A. ; Conrad, Don ; Enright, Anton J. ; Tyler-Smith, Chris ; Xue, Yali. / Exploration of signals of positive selection derived from genotype-based human genome scans using re-sequencing data. In: Human genetics. 2012 ; Vol. 131, No. 5. pp. 665-674.
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