TY - JOUR
T1 - Experimental (Re)structuring
T2 - The Clinical Trial as Turning Point Among Medical Research Participants
AU - Jaffe, Kaitlyn
AU - Korthuis, P. Todd
AU - Richardson, Lindsey
N1 - Publisher Copyright:
© The Author(s) 2021.
PY - 2021/7
Y1 - 2021/7
N2 - Amid the growth of addiction medicine randomized controlled trials (RCTs), scholars have begun examining participants’ study experiences, highlighting facilitators and barriers to enrollment. However, this work can overlook the interplay between trial participation and social-structural dimensions among people with substance use disorders linked to the social nature of use, socioeconomic marginalization, and time demands of substance procurement and use. To effectively conduct RCTs with this unique population, it is necessary to examine the broader social context of study participation. We conducted nested qualitative interviews with 22 participants involved in an RCT testing a treatment for alcohol and opioid use disorders in HIV clinics. Thematic analyses revealed social-structural circumstances shaping RCT participation as well as how participation constitutes a turning point, prompting individuals to reconfigure social networks, reorient to spatial environments, and reorganize day-to-day life—with implications for how substance use disorder RCTs should be approached by researchers.
AB - Amid the growth of addiction medicine randomized controlled trials (RCTs), scholars have begun examining participants’ study experiences, highlighting facilitators and barriers to enrollment. However, this work can overlook the interplay between trial participation and social-structural dimensions among people with substance use disorders linked to the social nature of use, socioeconomic marginalization, and time demands of substance procurement and use. To effectively conduct RCTs with this unique population, it is necessary to examine the broader social context of study participation. We conducted nested qualitative interviews with 22 participants involved in an RCT testing a treatment for alcohol and opioid use disorders in HIV clinics. Thematic analyses revealed social-structural circumstances shaping RCT participation as well as how participation constitutes a turning point, prompting individuals to reconfigure social networks, reorient to spatial environments, and reorganize day-to-day life—with implications for how substance use disorder RCTs should be approached by researchers.
KW - Canada
KW - lived experience
KW - marginalized or vulnerable populations
KW - qualitative interviews
KW - substance use
KW - users’ experiences
UR - http://www.scopus.com/inward/record.url?scp=85107298016&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107298016&partnerID=8YFLogxK
U2 - 10.1177/10497323211016408
DO - 10.1177/10497323211016408
M3 - Article
C2 - 34078194
AN - SCOPUS:85107298016
SN - 1049-7323
VL - 31
SP - 1504
EP - 1517
JO - Qualitative health research
JF - Qualitative health research
IS - 8
ER -