Experimental Ovine Model of Primary Venous Valve Incompetence

A Pilot Study

Won Kyu Park, Dusan Pavcnik, Brad Shirley, Wei Lu, Barry Uchida, Qiang (Michael) Yin, Hanno Hoppe, Man Kim Duck, Long Liu, Frederick Keller, Josef Rosch

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To compare two techniques used to create a larger animal model of venous valve incompetence. Materials and Methods: To achieve vein dilatation as the primary cause of valve incompetence, common carotid jugular vein (JV) fistulas were created and optional filters were placed into the JV of sheep. Altogether, nine inferior vena cava filters were placed in three sheep in two stages. Six filters were placed caudal to the most caudal JV valve in three sheep and removed 6 weeks later. Then, three filters were placed across the most caudal valve in two sheep with competent valves and removed 3 weeks later. A common carotid artery-JV fistula was created in three sheep and followed-up for 1-3 weeks. Ascending and descending venograms were obtained to determine the JV sizes and function of their valves. The JVs removed at necropsy were studied with venoscopy. Results: Only one of the six JVs with filters caudal to the most caudal valve had incompetent valves after filter removal at 6 weeks. In addition, only one of three JVs with the filter across the valve had incompetent valves after filter removal at 3 weeks. At 1-3-week follow-up of the group with common carotid artery-JV fistula, all three JVs had incompetent valves in the cephalad vein portion, but only one JV had an incompetent valve in its caudal portion. At venoscopy, the incompetent valves showed various degrees of damage ranging from shortening to the destruction of valve leaflets. Conclusion: Dilation of the valve annulus with a removable vena cava filter failed to produce valve incompetence. The promising results with the common carotid artery-JV fistula justify further detailed research.

Original languageEnglish (US)
Pages (from-to)1169-1175
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Volume18
Issue number9
DOIs
StatePublished - Sep 2007

Fingerprint

Venous Valves
Jugular Veins
Sheep
Theoretical Models
Fistula
Common Carotid Artery
Vena Cava Filters
Dilatation
Veins
Animal Models

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Experimental Ovine Model of Primary Venous Valve Incompetence : A Pilot Study. / Park, Won Kyu; Pavcnik, Dusan; Shirley, Brad; Lu, Wei; Uchida, Barry; Yin, Qiang (Michael); Hoppe, Hanno; Duck, Man Kim; Liu, Long; Keller, Frederick; Rosch, Josef.

In: Journal of Vascular and Interventional Radiology, Vol. 18, No. 9, 09.2007, p. 1169-1175.

Research output: Contribution to journalArticle

Park, WK, Pavcnik, D, Shirley, B, Lu, W, Uchida, B, Yin, QM, Hoppe, H, Duck, MK, Liu, L, Keller, F & Rosch, J 2007, 'Experimental Ovine Model of Primary Venous Valve Incompetence: A Pilot Study', Journal of Vascular and Interventional Radiology, vol. 18, no. 9, pp. 1169-1175. https://doi.org/10.1016/j.jvir.2007.06.001
Park, Won Kyu ; Pavcnik, Dusan ; Shirley, Brad ; Lu, Wei ; Uchida, Barry ; Yin, Qiang (Michael) ; Hoppe, Hanno ; Duck, Man Kim ; Liu, Long ; Keller, Frederick ; Rosch, Josef. / Experimental Ovine Model of Primary Venous Valve Incompetence : A Pilot Study. In: Journal of Vascular and Interventional Radiology. 2007 ; Vol. 18, No. 9. pp. 1169-1175.
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AU - Uchida, Barry

AU - Yin, Qiang (Michael)

AU - Hoppe, Hanno

AU - Duck, Man Kim

AU - Liu, Long

AU - Keller, Frederick

AU - Rosch, Josef

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AB - Purpose: To compare two techniques used to create a larger animal model of venous valve incompetence. Materials and Methods: To achieve vein dilatation as the primary cause of valve incompetence, common carotid jugular vein (JV) fistulas were created and optional filters were placed into the JV of sheep. Altogether, nine inferior vena cava filters were placed in three sheep in two stages. Six filters were placed caudal to the most caudal JV valve in three sheep and removed 6 weeks later. Then, three filters were placed across the most caudal valve in two sheep with competent valves and removed 3 weeks later. A common carotid artery-JV fistula was created in three sheep and followed-up for 1-3 weeks. Ascending and descending venograms were obtained to determine the JV sizes and function of their valves. The JVs removed at necropsy were studied with venoscopy. Results: Only one of the six JVs with filters caudal to the most caudal valve had incompetent valves after filter removal at 6 weeks. In addition, only one of three JVs with the filter across the valve had incompetent valves after filter removal at 3 weeks. At 1-3-week follow-up of the group with common carotid artery-JV fistula, all three JVs had incompetent valves in the cephalad vein portion, but only one JV had an incompetent valve in its caudal portion. At venoscopy, the incompetent valves showed various degrees of damage ranging from shortening to the destruction of valve leaflets. Conclusion: Dilation of the valve annulus with a removable vena cava filter failed to produce valve incompetence. The promising results with the common carotid artery-JV fistula justify further detailed research.

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