Experimental osteoarthritis in dogs

A comparison of the Pond-Nuki and medial arthrotomy methods

D. M. Visco, M. A. Hill, W. R. Widmer, Brian Johnstone, S. L. Myers

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Lesions induced by transecting the cranial cruciate ligament in two surgical models of osteoarthritis (OA) in mature, male, cross-bred dogs were compared by using an established grading system and alternatives. Previously, we relied on evaluations of lesions in articular cartilage on femurs alone. No statistically significant differences were found between grades for lesions in cartilage when either treated or control joints were compared by surgical method. Because the Pond-Nuki method yielded statistically significant differences between grades for lesions affecting treated and control femurs or tibias, and for some parameters indicative of synovitis, we preferred this method of surgery. Although by using the medial arthrotomy method of surgery, we were able to destabilize the joint in a more consistent manner, significant differences between treated and control joints were found for lesions on tibias, but not femurs, a frequent site for OA in humans. Suggestions are made for enhancing the surgical models and for a more holistic approach to evaluating joints morphologically.

Original languageEnglish (US)
Pages (from-to)9-22
Number of pages14
JournalOsteoarthritis and Cartilage
Volume4
Issue number1
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Ponds
Osteoarthritis
Joints
Cartilage
Dogs
Femur
Anatomic Models
Surgery
Tibia
Ligaments
Synovitis
Anterior Cruciate Ligament
Articular Cartilage

Keywords

  • Dog
  • Evaluation
  • Model
  • Osteoarthritis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Experimental osteoarthritis in dogs : A comparison of the Pond-Nuki and medial arthrotomy methods. / Visco, D. M.; Hill, M. A.; Widmer, W. R.; Johnstone, Brian; Myers, S. L.

In: Osteoarthritis and Cartilage, Vol. 4, No. 1, 1996, p. 9-22.

Research output: Contribution to journalArticle

Visco, D. M. ; Hill, M. A. ; Widmer, W. R. ; Johnstone, Brian ; Myers, S. L. / Experimental osteoarthritis in dogs : A comparison of the Pond-Nuki and medial arthrotomy methods. In: Osteoarthritis and Cartilage. 1996 ; Vol. 4, No. 1. pp. 9-22.
@article{6026e72349e04ce8a81aeada9fdf5f39,
title = "Experimental osteoarthritis in dogs: A comparison of the Pond-Nuki and medial arthrotomy methods",
abstract = "Lesions induced by transecting the cranial cruciate ligament in two surgical models of osteoarthritis (OA) in mature, male, cross-bred dogs were compared by using an established grading system and alternatives. Previously, we relied on evaluations of lesions in articular cartilage on femurs alone. No statistically significant differences were found between grades for lesions in cartilage when either treated or control joints were compared by surgical method. Because the Pond-Nuki method yielded statistically significant differences between grades for lesions affecting treated and control femurs or tibias, and for some parameters indicative of synovitis, we preferred this method of surgery. Although by using the medial arthrotomy method of surgery, we were able to destabilize the joint in a more consistent manner, significant differences between treated and control joints were found for lesions on tibias, but not femurs, a frequent site for OA in humans. Suggestions are made for enhancing the surgical models and for a more holistic approach to evaluating joints morphologically.",
keywords = "Dog, Evaluation, Model, Osteoarthritis",
author = "Visco, {D. M.} and Hill, {M. A.} and Widmer, {W. R.} and Brian Johnstone and Myers, {S. L.}",
year = "1996",
doi = "10.1016/S1063-4584(96)80003-3",
language = "English (US)",
volume = "4",
pages = "9--22",
journal = "Osteoarthritis and Cartilage",
issn = "1063-4584",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Experimental osteoarthritis in dogs

T2 - A comparison of the Pond-Nuki and medial arthrotomy methods

AU - Visco, D. M.

AU - Hill, M. A.

AU - Widmer, W. R.

AU - Johnstone, Brian

AU - Myers, S. L.

PY - 1996

Y1 - 1996

N2 - Lesions induced by transecting the cranial cruciate ligament in two surgical models of osteoarthritis (OA) in mature, male, cross-bred dogs were compared by using an established grading system and alternatives. Previously, we relied on evaluations of lesions in articular cartilage on femurs alone. No statistically significant differences were found between grades for lesions in cartilage when either treated or control joints were compared by surgical method. Because the Pond-Nuki method yielded statistically significant differences between grades for lesions affecting treated and control femurs or tibias, and for some parameters indicative of synovitis, we preferred this method of surgery. Although by using the medial arthrotomy method of surgery, we were able to destabilize the joint in a more consistent manner, significant differences between treated and control joints were found for lesions on tibias, but not femurs, a frequent site for OA in humans. Suggestions are made for enhancing the surgical models and for a more holistic approach to evaluating joints morphologically.

AB - Lesions induced by transecting the cranial cruciate ligament in two surgical models of osteoarthritis (OA) in mature, male, cross-bred dogs were compared by using an established grading system and alternatives. Previously, we relied on evaluations of lesions in articular cartilage on femurs alone. No statistically significant differences were found between grades for lesions in cartilage when either treated or control joints were compared by surgical method. Because the Pond-Nuki method yielded statistically significant differences between grades for lesions affecting treated and control femurs or tibias, and for some parameters indicative of synovitis, we preferred this method of surgery. Although by using the medial arthrotomy method of surgery, we were able to destabilize the joint in a more consistent manner, significant differences between treated and control joints were found for lesions on tibias, but not femurs, a frequent site for OA in humans. Suggestions are made for enhancing the surgical models and for a more holistic approach to evaluating joints morphologically.

KW - Dog

KW - Evaluation

KW - Model

KW - Osteoarthritis

UR - http://www.scopus.com/inward/record.url?scp=0030004894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030004894&partnerID=8YFLogxK

U2 - 10.1016/S1063-4584(96)80003-3

DO - 10.1016/S1063-4584(96)80003-3

M3 - Article

VL - 4

SP - 9

EP - 22

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

SN - 1063-4584

IS - 1

ER -