Experimental neuropathy produced by 2,5-hexanedione- a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone

Peter Spencer, Herbert H. Schaumburg

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Chronic exposure of rats to 2,5-hexanedione (CH3COCH 2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone (CH3COCH 2CH2CH2CH3), has been shown to cause a clinical peripheral neuropathy with dying-back peripheral and central nervous system degeneration characterized by giant axonal swellings filled with neurofilaments. This pattern of disease is similar to that produced by methyl n-butyl ketone.

Original languageEnglish (US)
Pages (from-to)771-775
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume38
Issue number8
DOIs
StatePublished - 1975
Externally publishedYes

Fingerprint

Methyl n-Butyl Ketone
Intermediate Filaments
Peripheral Nervous System
Peripheral Nervous System Diseases
Central Nervous System
2,5-hexanedione

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

@article{4f5ad1d3898547e89594782def20be38,
title = "Experimental neuropathy produced by 2,5-hexanedione- a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone",
abstract = "Chronic exposure of rats to 2,5-hexanedione (CH3COCH 2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone (CH3COCH 2CH2CH2CH3), has been shown to cause a clinical peripheral neuropathy with dying-back peripheral and central nervous system degeneration characterized by giant axonal swellings filled with neurofilaments. This pattern of disease is similar to that produced by methyl n-butyl ketone.",
author = "Peter Spencer and Schaumburg, {Herbert H.}",
year = "1975",
doi = "10.1136/jnnp.38.8.771",
language = "English (US)",
volume = "38",
pages = "771--775",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "8",

}

TY - JOUR

T1 - Experimental neuropathy produced by 2,5-hexanedione- a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone

AU - Spencer, Peter

AU - Schaumburg, Herbert H.

PY - 1975

Y1 - 1975

N2 - Chronic exposure of rats to 2,5-hexanedione (CH3COCH 2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone (CH3COCH 2CH2CH2CH3), has been shown to cause a clinical peripheral neuropathy with dying-back peripheral and central nervous system degeneration characterized by giant axonal swellings filled with neurofilaments. This pattern of disease is similar to that produced by methyl n-butyl ketone.

AB - Chronic exposure of rats to 2,5-hexanedione (CH3COCH 2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone (CH3COCH 2CH2CH2CH3), has been shown to cause a clinical peripheral neuropathy with dying-back peripheral and central nervous system degeneration characterized by giant axonal swellings filled with neurofilaments. This pattern of disease is similar to that produced by methyl n-butyl ketone.

UR - http://www.scopus.com/inward/record.url?scp=0016820609&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016820609&partnerID=8YFLogxK

U2 - 10.1136/jnnp.38.8.771

DO - 10.1136/jnnp.38.8.771

M3 - Article

VL - 38

SP - 771

EP - 775

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 8

ER -