Experimental neuropathy produced by 2,5-hexanedione- a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone

Peter S. Spencer, Herbert H. Schaumburg

Research output: Contribution to journalArticle

149 Scopus citations

Abstract

Chronic exposure of rats to 2,5-hexanedione (CH3COCH 2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone (CH3COCH 2CH2CH2CH3), has been shown to cause a clinical peripheral neuropathy with dying-back peripheral and central nervous system degeneration characterized by giant axonal swellings filled with neurofilaments. This pattern of disease is similar to that produced by methyl n-butyl ketone.

Original languageEnglish (US)
Pages (from-to)771-775
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume38
Issue number8
DOIs
StatePublished - 1975

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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