TY - JOUR
T1 - Experimental neuropathy produced by 2,5-hexanedione- a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone
AU - Spencer, Peter S.
AU - Schaumburg, Herbert H.
PY - 1975
Y1 - 1975
N2 - Chronic exposure of rats to 2,5-hexanedione (CH3COCH 2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone (CH3COCH 2CH2CH2CH3), has been shown to cause a clinical peripheral neuropathy with dying-back peripheral and central nervous system degeneration characterized by giant axonal swellings filled with neurofilaments. This pattern of disease is similar to that produced by methyl n-butyl ketone.
AB - Chronic exposure of rats to 2,5-hexanedione (CH3COCH 2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone (CH3COCH 2CH2CH2CH3), has been shown to cause a clinical peripheral neuropathy with dying-back peripheral and central nervous system degeneration characterized by giant axonal swellings filled with neurofilaments. This pattern of disease is similar to that produced by methyl n-butyl ketone.
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U2 - 10.1136/jnnp.38.8.771
DO - 10.1136/jnnp.38.8.771
M3 - Article
C2 - 171344
AN - SCOPUS:0016820609
SN - 0022-3050
VL - 38
SP - 771
EP - 775
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
IS - 8
ER -