Experimental Models of Stress and Wound Healing

John F. Sheridan, David A. Padgett, Ronit Avitsur, Phillip Marucha

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Experimental animal models have been used to examine stress-induced interactions among the nervous, endocrine, and immune systems. Generally, the response to stress results in a body-wide set of physiologic adaptations, mediated through the activation of neuroendocrine pathways that intersect and modulate inflammatory and immune responses. These interacting responses modulate diverse physiological processes including the initiation of tissue repair and wound healing. Two different stressors were used to activate neuroendocrine responses to study their impact on wound healing: restraint (RST) and social disruption (SDR). Previous studies showed that both stressors activate the hypothalamic-pituitary-adrenal (HPA) axis, resulting in elevated plasma levels of the corticosterone (cort) response and modulation of pro-inflammatory cytokine response. To test the effects of stress-induced HPA activation on inflammatory responses and wound healing, a 3.5-mm cutaneous punch biopsy wound was placed on the dorsal surface of control and stressed (RST or SDR) C57BL/6 male mice and the kinetics of wound healing were studied over 10 days. RST slowed wound healing in inbred C57BL/6 mice, whereas the wounds on SDR mice healed in a fashion similar to the non-stressed, home cage controls.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalWorld Journal of Surgery
Volume28
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

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Wound Healing
Theoretical Models
Physiological Phenomena
Physiological Adaptation
Endocrine System
Wounds and Injuries
Corticosterone
Exercise Test
Inbred C57BL Mouse
Nervous System
Immune System
Animal Models
Cytokines
Biopsy
Skin

ASJC Scopus subject areas

  • Surgery

Cite this

Experimental Models of Stress and Wound Healing. / Sheridan, John F.; Padgett, David A.; Avitsur, Ronit; Marucha, Phillip.

In: World Journal of Surgery, Vol. 28, No. 3, 03.2004, p. 327-330.

Research output: Contribution to journalArticle

Sheridan, John F. ; Padgett, David A. ; Avitsur, Ronit ; Marucha, Phillip. / Experimental Models of Stress and Wound Healing. In: World Journal of Surgery. 2004 ; Vol. 28, No. 3. pp. 327-330.
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