Experimental Combined Systemic and Local Chemotherapy for Intraocular Malignancy

Hsiao S. Liu, Miguel F. Refojo, Daniel Albert

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

• Greene melanoma was transplanted into the anterior chamber of rabbit eyes. These animal models were divided into four groups. Group 1 received carmustine (1,3 bis [2-chloroethyl]-1-nitrosourea) intravenously. Group 2 received the drug by sub-Tenon-retrobulbar (periocular) injection. Group 3 received both periocular and intravenous administration; the combined dose was the same as that in group 1. Group 4 served as untreated control. The effectiveness of the various administration routes was compared by clinical observation of the size of the tumor growing in the eye, weight of the enucleated eyes, and histopathologic examination. Administration of carmustine delayed the growth of Greene melanoma in rabbit eye of all three treated groups, but effectiveness of treatment was considerably enhanced by combining periocular and intravenous administration of a lower dose of carmustine.

Original languageEnglish (US)
Pages (from-to)905-908
Number of pages4
JournalArchives of ophthalmology
Volume98
Issue number5
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

Fingerprint

Carmustine
Drug Therapy
Intravenous Administration
Melanoma
Neoplasms
Intraocular Injections
Rabbits
Anterior Chamber
Animal Models
Observation
Weights and Measures
Growth
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Experimental Combined Systemic and Local Chemotherapy for Intraocular Malignancy. / Liu, Hsiao S.; Refojo, Miguel F.; Albert, Daniel.

In: Archives of ophthalmology, Vol. 98, No. 5, 01.01.1980, p. 905-908.

Research output: Contribution to journalArticle

@article{e1f6659e505840cb8504eb60dde68fa0,
title = "Experimental Combined Systemic and Local Chemotherapy for Intraocular Malignancy",
abstract = "• Greene melanoma was transplanted into the anterior chamber of rabbit eyes. These animal models were divided into four groups. Group 1 received carmustine (1,3 bis [2-chloroethyl]-1-nitrosourea) intravenously. Group 2 received the drug by sub-Tenon-retrobulbar (periocular) injection. Group 3 received both periocular and intravenous administration; the combined dose was the same as that in group 1. Group 4 served as untreated control. The effectiveness of the various administration routes was compared by clinical observation of the size of the tumor growing in the eye, weight of the enucleated eyes, and histopathologic examination. Administration of carmustine delayed the growth of Greene melanoma in rabbit eye of all three treated groups, but effectiveness of treatment was considerably enhanced by combining periocular and intravenous administration of a lower dose of carmustine.",
author = "Liu, {Hsiao S.} and Refojo, {Miguel F.} and Daniel Albert",
year = "1980",
month = "1",
day = "1",
doi = "10.1001/archopht.1980.01020030899019",
language = "English (US)",
volume = "98",
pages = "905--908",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "5",

}

TY - JOUR

T1 - Experimental Combined Systemic and Local Chemotherapy for Intraocular Malignancy

AU - Liu, Hsiao S.

AU - Refojo, Miguel F.

AU - Albert, Daniel

PY - 1980/1/1

Y1 - 1980/1/1

N2 - • Greene melanoma was transplanted into the anterior chamber of rabbit eyes. These animal models were divided into four groups. Group 1 received carmustine (1,3 bis [2-chloroethyl]-1-nitrosourea) intravenously. Group 2 received the drug by sub-Tenon-retrobulbar (periocular) injection. Group 3 received both periocular and intravenous administration; the combined dose was the same as that in group 1. Group 4 served as untreated control. The effectiveness of the various administration routes was compared by clinical observation of the size of the tumor growing in the eye, weight of the enucleated eyes, and histopathologic examination. Administration of carmustine delayed the growth of Greene melanoma in rabbit eye of all three treated groups, but effectiveness of treatment was considerably enhanced by combining periocular and intravenous administration of a lower dose of carmustine.

AB - • Greene melanoma was transplanted into the anterior chamber of rabbit eyes. These animal models were divided into four groups. Group 1 received carmustine (1,3 bis [2-chloroethyl]-1-nitrosourea) intravenously. Group 2 received the drug by sub-Tenon-retrobulbar (periocular) injection. Group 3 received both periocular and intravenous administration; the combined dose was the same as that in group 1. Group 4 served as untreated control. The effectiveness of the various administration routes was compared by clinical observation of the size of the tumor growing in the eye, weight of the enucleated eyes, and histopathologic examination. Administration of carmustine delayed the growth of Greene melanoma in rabbit eye of all three treated groups, but effectiveness of treatment was considerably enhanced by combining periocular and intravenous administration of a lower dose of carmustine.

UR - http://www.scopus.com/inward/record.url?scp=0018825176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018825176&partnerID=8YFLogxK

U2 - 10.1001/archopht.1980.01020030899019

DO - 10.1001/archopht.1980.01020030899019

M3 - Article

C2 - 7378013

AN - SCOPUS:0018825176

VL - 98

SP - 905

EP - 908

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 5

ER -