Abstract
Summary: Male and female Guinea pigs underwent immunisation with heterologous heart protein (rat heart), complete Freund's adjuvant and pertussis vaccine (immunised) or normal saline (control) at weekly intervals for 6 weeks, and were subsequently studied. In vivo intracardiac pressures, cardiac outputs, blood volumes, in vitro pressure-volume relations, left ventricular collagen contents, light microscopy, direct immunofluorescence, lymphocyte stimulation studies, and serology for circulating anti heart antibody (haemagglutination and radioimmunoassay) were performed. Immunised Guinea pigs studied between 5 and 8 weeks following the immunisation protocol demonstrated a 44% increase in LVEDP (p
Original language | English (US) |
---|---|
Pages (from-to) | 613-622 |
Number of pages | 10 |
Journal | Cardiovascular Research |
Volume | 19 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1985 |
Keywords
- Autoimmune
- Cardiomyopathy
- Myocardial dysfunction
- Myocarditis
ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Physiology (medical)
- Physiology
- Cardiology and Cardiovascular Medicine