Experimental autoimmune myocarditis in the Guinea pig

Jeffrey D. Hosenpud, Stephen M. Campbell, Mark V. Hart, Marilyn S. Paul, John R. Rowles, Nelson (Sam) Niles

Research output: Contribution to journalArticle

Abstract

Summary: Male and female Guinea pigs underwent immunisation with heterologous heart protein (rat heart), complete Freund's adjuvant and pertussis vaccine (immunised) or normal saline (control) at weekly intervals for 6 weeks, and were subsequently studied. In vivo intracardiac pressures, cardiac outputs, blood volumes, in vitro pressure-volume relations, left ventricular collagen contents, light microscopy, direct immunofluorescence, lymphocyte stimulation studies, and serology for circulating anti heart antibody (haemagglutination and radioimmunoassay) were performed. Immunised Guinea pigs studied between 5 and 8 weeks following the immunisation protocol demonstrated a 44% increase in LVEDP (p

Original languageEnglish (US)
Pages (from-to)613-622
Number of pages10
JournalCardiovascular Research
Volume19
Issue number10
DOIs
StatePublished - Oct 1985

Fingerprint

Myocarditis
Guinea pig
Immunization
Guinea Pigs
Rat Heart
Cardiac Output
Collagen
Lymphocytes
Vaccine
Antibody
Microscopy
Pertussis Vaccine
Blood
Pressure
Direct Fluorescent Antibody Technique
Vaccines
Freund's Adjuvant
Hemagglutination
Serology
Lymphocyte Activation

Keywords

  • Autoimmune
  • Cardiomyopathy
  • Myocardial dysfunction
  • Myocarditis

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Hosenpud, J. D., Campbell, S. M., Hart, M. V., Paul, M. S., Rowles, J. R., & Niles, N. S. (1985). Experimental autoimmune myocarditis in the Guinea pig. Cardiovascular Research, 19(10), 613-622. https://doi.org/10.1093/cvrese/19.10.613

Experimental autoimmune myocarditis in the Guinea pig. / Hosenpud, Jeffrey D.; Campbell, Stephen M.; Hart, Mark V.; Paul, Marilyn S.; Rowles, John R.; Niles, Nelson (Sam).

In: Cardiovascular Research, Vol. 19, No. 10, 10.1985, p. 613-622.

Research output: Contribution to journalArticle

Hosenpud, JD, Campbell, SM, Hart, MV, Paul, MS, Rowles, JR & Niles, NS 1985, 'Experimental autoimmune myocarditis in the Guinea pig', Cardiovascular Research, vol. 19, no. 10, pp. 613-622. https://doi.org/10.1093/cvrese/19.10.613
Hosenpud JD, Campbell SM, Hart MV, Paul MS, Rowles JR, Niles NS. Experimental autoimmune myocarditis in the Guinea pig. Cardiovascular Research. 1985 Oct;19(10):613-622. https://doi.org/10.1093/cvrese/19.10.613
Hosenpud, Jeffrey D. ; Campbell, Stephen M. ; Hart, Mark V. ; Paul, Marilyn S. ; Rowles, John R. ; Niles, Nelson (Sam). / Experimental autoimmune myocarditis in the Guinea pig. In: Cardiovascular Research. 1985 ; Vol. 19, No. 10. pp. 613-622.
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