Experimental autoimmune myocarditis in the Guinea pig

Jeffrey D. Hosenpud, Stephen M. Campbell, Mark V. Hart, Marilyn S. Paul, John R. Rowles, Nelson (Sam) Niles

Research output: Contribution to journalArticle

Abstract

Summary: Male and female Guinea pigs underwent immunisation with heterologous heart protein (rat heart), complete Freund's adjuvant and pertussis vaccine (immunised) or normal saline (control) at weekly intervals for 6 weeks, and were subsequently studied. In vivo intracardiac pressures, cardiac outputs, blood volumes, in vitro pressure-volume relations, left ventricular collagen contents, light microscopy, direct immunofluorescence, lymphocyte stimulation studies, and serology for circulating anti heart antibody (haemagglutination and radioimmunoassay) were performed. Immunised Guinea pigs studied between 5 and 8 weeks following the immunisation protocol demonstrated a 44% increase in LVEDP (p

Original languageEnglish (US)
Pages (from-to)613-622
Number of pages10
JournalCardiovascular Research
Volume19
Issue number10
DOIs
StatePublished - Oct 1985

Keywords

  • Autoimmune
  • Cardiomyopathy
  • Myocardial dysfunction
  • Myocarditis

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Hosenpud, J. D., Campbell, S. M., Hart, M. V., Paul, M. S., Rowles, J. R., & Niles, N. S. (1985). Experimental autoimmune myocarditis in the Guinea pig. Cardiovascular Research, 19(10), 613-622. https://doi.org/10.1093/cvrese/19.10.613