Experimental autoimmune encephalomyelitis mediated by T lymphocyte lines: Genotype of antigen-presenting cells influences immunodominant epitope of basic protein

E. Beraud, T. Reshef, A. A. Vandenbark, H. Offner, R. Friz, C. H. Chou, D. Bernard, I. R. Cohen

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Lewis rats are susceptible to experimental autoimmune encephalomyelitis (EAE), and their T lymphocytes recognize epitopes in the 68-88 sequence of guinea pig myelin basic protein (BP). BN rats are resistant to EAE, and their T lymphocytes recognize epitopes outside of the 68-88 sequence, probably in the 43-67 portion of BP. To investigate the influence of the genome of antigen-presenting cells (APC) on the dominance of BP epitopes for T lymphocyte lines, we selected anti-BP lines from (Lewis x BN)F1 rats by using the APC of Lewis, BN, or F1 origin. We now report that the F1/Lewis lines recognized the 68-88 epitopes and were highly encephalitogenic in F1 rats, whereas the F1/BN line recognized the 43-67 epitopes and was only weakly encephalitogenic. Thus, the genotype of the APC can influence the immunologic dominance for T lymphocytes of BP epitopes, and this dominance in turn can influence the expression of disease.

Original languageEnglish (US)
Pages (from-to)511-515
Number of pages5
JournalJournal of Immunology
Volume136
Issue number2
StatePublished - Apr 3 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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