TY - JOUR
T1 - Experimental autoimmune encephalomyelitis mediated by T lymphocyte lines
T2 - Genotype of antigen-presenting cells influences immunodominant epitope of basic protein
AU - Beraud, E.
AU - Reshef, T.
AU - Vandenbark, A. A.
AU - Offner, H.
AU - Friz, R.
AU - Chou, C. H.
AU - Bernard, D.
AU - Cohen, I. R.
PY - 1986
Y1 - 1986
N2 - Lewis rats are susceptible to experimental autoimmune encephalomyelitis (EAE), and their T lymphocytes recognize epitopes in the 68-88 sequence of guinea pig myelin basic protein (BP). BN rats are resistant to EAE, and their T lymphocytes recognize epitopes outside of the 68-88 sequence, probably in the 43-67 portion of BP. To investigate the influence of the genome of antigen-presenting cells (APC) on the dominance of BP epitopes for T lymphocyte lines, we selected anti-BP lines from (Lewis x BN)F1 rats by using the APC of Lewis, BN, or F1 origin. We now report that the F1/Lewis lines recognized the 68-88 epitopes and were highly encephalitogenic in F1 rats, whereas the F1/BN line recognized the 43-67 epitopes and was only weakly encephalitogenic. Thus, the genotype of the APC can influence the immunologic dominance for T lymphocytes of BP epitopes, and this dominance in turn can influence the expression of disease.
AB - Lewis rats are susceptible to experimental autoimmune encephalomyelitis (EAE), and their T lymphocytes recognize epitopes in the 68-88 sequence of guinea pig myelin basic protein (BP). BN rats are resistant to EAE, and their T lymphocytes recognize epitopes outside of the 68-88 sequence, probably in the 43-67 portion of BP. To investigate the influence of the genome of antigen-presenting cells (APC) on the dominance of BP epitopes for T lymphocyte lines, we selected anti-BP lines from (Lewis x BN)F1 rats by using the APC of Lewis, BN, or F1 origin. We now report that the F1/Lewis lines recognized the 68-88 epitopes and were highly encephalitogenic in F1 rats, whereas the F1/BN line recognized the 43-67 epitopes and was only weakly encephalitogenic. Thus, the genotype of the APC can influence the immunologic dominance for T lymphocytes of BP epitopes, and this dominance in turn can influence the expression of disease.
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M3 - Article
C2 - 2416808
AN - SCOPUS:0022631156
SN - 0022-1767
VL - 136
SP - 511
EP - 515
JO - Journal of Immunology
JF - Journal of Immunology
IS - 2
ER -