Experimental approaches to the study of epigenomic dysregulation in ageing

Reid F. Thompson; Melissa J. Fazzari; John M. Greally

doi:10.1016/j.exger.2009.12.013

Experimental approaches to the study of epigenomic dysregulation in ageing

Reid F. Thompson, Melissa J. Fazzari, John M. Greally

Research output: Contribution to journal › Short survey › peer-review

17 Scopus citations

Abstract

In this review, we describe how normal ageing may involve the acquisition of epigenetic errors over time, akin to the accumulation of genetic mutations with ageing. We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research.

Original language	English (US)
Pages (from-to)	255-268
Number of pages	14
Journal	Experimental Gerontology
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/j.exger.2009.12.013
State	Published - Apr 2010
Externally published	Yes

Keywords

Aging
Chromatin
DNA methylation
Epigenetic
Microarray

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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10.1016/j.exger.2009.12.013

Cite this

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title = "Experimental approaches to the study of epigenomic dysregulation in ageing",

abstract = "In this review, we describe how normal ageing may involve the acquisition of epigenetic errors over time, akin to the accumulation of genetic mutations with ageing. We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research.",

keywords = "Aging, Chromatin, DNA methylation, Epigenetic, Microarray",

author = "Thompson, {Reid F.} and Fazzari, {Melissa J.} and Greally, {John M.}",

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AU - Fazzari, Melissa J.

AU - Greally, John M.

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N2 - In this review, we describe how normal ageing may involve the acquisition of epigenetic errors over time, akin to the accumulation of genetic mutations with ageing. We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research.

AB - In this review, we describe how normal ageing may involve the acquisition of epigenetic errors over time, akin to the accumulation of genetic mutations with ageing. We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research.

KW - Aging

KW - Chromatin

KW - DNA methylation

KW - Epigenetic

KW - Microarray

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Experimental approaches to the study of epigenomic dysregulation in ageing

Abstract

Keywords

ASJC Scopus subject areas

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