Experimental approaches to the study of epigenomic dysregulation in ageing

Reid F. Thompson, Melissa J. Fazzari, John M. Greally

Research output: Contribution to journalShort survey

15 Scopus citations

Abstract

In this review, we describe how normal ageing may involve the acquisition of epigenetic errors over time, akin to the accumulation of genetic mutations with ageing. We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research.

Original languageEnglish (US)
Pages (from-to)255-268
Number of pages14
JournalExperimental Gerontology
Volume45
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • Aging
  • Chromatin
  • DNA methylation
  • Epigenetic
  • Microarray

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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