Experiences with a new ergoline (CF 25-397) in parkinsonism

Paul F. Teychenne, Ronald Pfeiffer, Stanley M. Bern, Donald B. Calne

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Studies on rats with unilateral nigral lesions suggest that a new ergoline, CF 25-397, is a dopaminergic agonist that might improve parkinsonism. CF 25-397 induces less stereotyped behavior than other dopaminergic agents in rats, and might therefore cause less dyskinesia than levodopa in man. We investigated the clinical actions of CF 25-397 in nine patients. During treatment, severe deterioration resulted in hypokinesia and rigidity; five patients showed marked dysphagia and dysphonia. There was statistically significant deterioration in four timed tests. Mild improvement, not statistically significant, was noted in tremor. These results indicate that clinical implication of the response to potential therapeutic agents in rodent models of parkinsonism must be interpreted with caution.

Original languageEnglish (US)
Pages (from-to)1140-1143
Number of pages4
JournalNeurology
Volume27
Issue number12
DOIs
StatePublished - Dec 1977

ASJC Scopus subject areas

  • Clinical Neurology

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