Expanding the molecular glycophenotype ontology to include model organisms and acquired diseases

Jean Philippe Gourdine, Nicole Vasilevsky, Lilly Winfree, Matthew Brush, Melissa Haendel

Research output: Contribution to journalConference article

Abstract

Glycans are an underappreciated class of molecules despite the fact that they are implicated in more than 100 known diseases. We have developed an ontology model that captures glycan abnormalities at the molecular level (glycophenotypes) called the molecular glycophenotype ontology (MGPO). Only 30% of known glycosyltransferases have been implicated in human genetic disorders of glycosylation. Ortholog glycosyltransferases from model organism can cover relevant biological information on potential human diseases. Thus, extending MGPO to represent additional phenotypes and support annotation of model organism data will help cross-species comparison. Expansion of MGPO will also include annotation of glycophenotypes from acquired diseases.

Original languageEnglish (US)
JournalCEUR Workshop Proceedings
Volume2285
StatePublished - Jan 1 2018
Event9th International Conference on Biological Ontology, ICBO 2018 - Corvallis, United States
Duration: Aug 7 2018Aug 10 2018

Keywords

  • Diseases
  • Glycans
  • Glycophenotypes
  • Model organisms

ASJC Scopus subject areas

  • Computer Science(all)

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