Exocytosis unbound

Ko Matsui, Craig Jahr

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The accepted theory of vesicular release of neurotransmitter posits that only a single vesicle per synapse can fuse with the membrane following action potential invasion, and this exocytotic event is limited to the ultrastructurally defined presynaptic active zone. Neither of these dictums is universally true. At certain synapses, more than a single vesicle can be released per action potential, and there is growing evidence that neuronal exocytosis can occur from sites that are unremarkable in electron micrographs. The first discrepancy extends the dynamic range of synapses, whereas the second enables faster and more robust chemical transmission at sites distant from morphologically defined synapses. Taken together, these attributes expand the capabilities of cellular communication in the nervous system.

Original languageEnglish (US)
Pages (from-to)305-311
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume16
Issue number3
DOIs
StatePublished - Jun 2006

Fingerprint

Exocytosis
Synapses
Action Potentials
Nervous System
Neurotransmitter Agents
Electrons
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Exocytosis unbound. / Matsui, Ko; Jahr, Craig.

In: Current Opinion in Neurobiology, Vol. 16, No. 3, 06.2006, p. 305-311.

Research output: Contribution to journalArticle

Matsui, K & Jahr, C 2006, 'Exocytosis unbound', Current Opinion in Neurobiology, vol. 16, no. 3, pp. 305-311. https://doi.org/10.1016/j.conb.2006.04.001
Matsui, Ko ; Jahr, Craig. / Exocytosis unbound. In: Current Opinion in Neurobiology. 2006 ; Vol. 16, No. 3. pp. 305-311.
@article{34d40f29197c431b9650f4263675ece0,
title = "Exocytosis unbound",
abstract = "The accepted theory of vesicular release of neurotransmitter posits that only a single vesicle per synapse can fuse with the membrane following action potential invasion, and this exocytotic event is limited to the ultrastructurally defined presynaptic active zone. Neither of these dictums is universally true. At certain synapses, more than a single vesicle can be released per action potential, and there is growing evidence that neuronal exocytosis can occur from sites that are unremarkable in electron micrographs. The first discrepancy extends the dynamic range of synapses, whereas the second enables faster and more robust chemical transmission at sites distant from morphologically defined synapses. Taken together, these attributes expand the capabilities of cellular communication in the nervous system.",
author = "Ko Matsui and Craig Jahr",
year = "2006",
month = "6",
doi = "10.1016/j.conb.2006.04.001",
language = "English (US)",
volume = "16",
pages = "305--311",
journal = "Current Opinion in Neurobiology",
issn = "0959-4388",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Exocytosis unbound

AU - Matsui, Ko

AU - Jahr, Craig

PY - 2006/6

Y1 - 2006/6

N2 - The accepted theory of vesicular release of neurotransmitter posits that only a single vesicle per synapse can fuse with the membrane following action potential invasion, and this exocytotic event is limited to the ultrastructurally defined presynaptic active zone. Neither of these dictums is universally true. At certain synapses, more than a single vesicle can be released per action potential, and there is growing evidence that neuronal exocytosis can occur from sites that are unremarkable in electron micrographs. The first discrepancy extends the dynamic range of synapses, whereas the second enables faster and more robust chemical transmission at sites distant from morphologically defined synapses. Taken together, these attributes expand the capabilities of cellular communication in the nervous system.

AB - The accepted theory of vesicular release of neurotransmitter posits that only a single vesicle per synapse can fuse with the membrane following action potential invasion, and this exocytotic event is limited to the ultrastructurally defined presynaptic active zone. Neither of these dictums is universally true. At certain synapses, more than a single vesicle can be released per action potential, and there is growing evidence that neuronal exocytosis can occur from sites that are unremarkable in electron micrographs. The first discrepancy extends the dynamic range of synapses, whereas the second enables faster and more robust chemical transmission at sites distant from morphologically defined synapses. Taken together, these attributes expand the capabilities of cellular communication in the nervous system.

UR - http://www.scopus.com/inward/record.url?scp=33746918049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746918049&partnerID=8YFLogxK

U2 - 10.1016/j.conb.2006.04.001

DO - 10.1016/j.conb.2006.04.001

M3 - Article

C2 - 16675216

AN - SCOPUS:33746918049

VL - 16

SP - 305

EP - 311

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

SN - 0959-4388

IS - 3

ER -