EXO1-A multi-tasking eukaryotic nuclease

Phuoc T. Tran, Naz Erdeniz, Lorraine S. Symington, Robert (Mike) Liskay

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Exo1 was first isolated as a 5′ → 3′ exonuclease activity induced during meiosis in fission yeast and since that time has been implicated in a multitude of eukaryotic DNA metabolic pathways that include DNA repair, recombination, replication, and telomere integrity. Involvement in multiple pathways affecting genomic stability makes EXO1 a logical target for mutation during oncogenesis. Here, we review studies in several experimental systems that shed light on the role of Exo1 in these DNA transaction pathways, particularly those that may relate to oncogenesis.

Original languageEnglish (US)
Pages (from-to)1549-1559
Number of pages11
JournalDNA Repair
Volume3
Issue number12
DOIs
StatePublished - Dec 2 2004

Fingerprint

Multitasking
Carcinogenesis
Exonucleases
Schizosaccharomyces
Genomic Instability
DNA
Telomere
Meiosis
Metabolic Networks and Pathways
DNA Repair
Genetic Recombination
Yeast
Mutation
Repair

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Tran, P. T., Erdeniz, N., Symington, L. S., & Liskay, R. M. (2004). EXO1-A multi-tasking eukaryotic nuclease. DNA Repair, 3(12), 1549-1559. https://doi.org/10.1016/j.dnarep.2004.05.015

EXO1-A multi-tasking eukaryotic nuclease. / Tran, Phuoc T.; Erdeniz, Naz; Symington, Lorraine S.; Liskay, Robert (Mike).

In: DNA Repair, Vol. 3, No. 12, 02.12.2004, p. 1549-1559.

Research output: Contribution to journalArticle

Tran, PT, Erdeniz, N, Symington, LS & Liskay, RM 2004, 'EXO1-A multi-tasking eukaryotic nuclease', DNA Repair, vol. 3, no. 12, pp. 1549-1559. https://doi.org/10.1016/j.dnarep.2004.05.015
Tran PT, Erdeniz N, Symington LS, Liskay RM. EXO1-A multi-tasking eukaryotic nuclease. DNA Repair. 2004 Dec 2;3(12):1549-1559. https://doi.org/10.1016/j.dnarep.2004.05.015
Tran, Phuoc T. ; Erdeniz, Naz ; Symington, Lorraine S. ; Liskay, Robert (Mike). / EXO1-A multi-tasking eukaryotic nuclease. In: DNA Repair. 2004 ; Vol. 3, No. 12. pp. 1549-1559.
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