Exhaled nitric oxide during exercise: Site of release and modulation by ventilation and blood flow

Charles R. Phillips, George D. Giraud, William E. Holden

    Research output: Contribution to journalArticle

    75 Scopus citations

    Abstract

    To define the site of release and factors modulating exhaled nitric oxide (NO) during exercise in humans, we measured exhaled NO output during exercise, during exercise after balloon occlusion of the nasopharynx (to exclude nasal NO), and at rest with isocapneic hyperventilation or dobutamine infusion. Exhaled NO output increased from rest to exercise (57 ± 10 to 171 ± 30 nl · min-1 · m-2; p < 0.003; n = 8). Exclusion of nasal NO reduced exhaled NO at rest and during exercise. Calculated nasal contribution at rest (53 ± 5%) decreased during exercise (29 ± 6%; P < 0.05), whereas nonnasal contribution increased (47 ± 5 to 71 ± 6%; P < 0.05). Isocapneic hyperventilation at rest increased exhaled NO output (51 ± 8 to 94 ± 22 nl · min-1 · m-2; P = 0.05). Dobutamine infusion did not increase exhaled NO output. We conclude that nasal exhaled NO decreases (and nonnasal exhaled NO increases) with exercise. We also conclude that, under the conditions of this study, increased exhaled NO output during exercise is more closely related to increased ventilation than to increased blood flow.

    Original languageEnglish (US)
    Pages (from-to)1865-1871
    Number of pages7
    JournalJournal of Applied Physiology
    Volume80
    Issue number6
    DOIs
    StatePublished - Jun 1996

    Keywords

    • nasal
    • nose

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)

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