TY - JOUR
T1 - Exhaled nitric oxide during exercise
T2 - Site of release and modulation by ventilation and blood flow
AU - Phillips, Charles R.
AU - Giraud, George D.
AU - Holden, William E.
PY - 1996/6
Y1 - 1996/6
N2 - To define the site of release and factors modulating exhaled nitric oxide (NO) during exercise in humans, we measured exhaled NO output during exercise, during exercise after balloon occlusion of the nasopharynx (to exclude nasal NO), and at rest with isocapneic hyperventilation or dobutamine infusion. Exhaled NO output increased from rest to exercise (57 ± 10 to 171 ± 30 nl · min-1 · m-2; p < 0.003; n = 8). Exclusion of nasal NO reduced exhaled NO at rest and during exercise. Calculated nasal contribution at rest (53 ± 5%) decreased during exercise (29 ± 6%; P < 0.05), whereas nonnasal contribution increased (47 ± 5 to 71 ± 6%; P < 0.05). Isocapneic hyperventilation at rest increased exhaled NO output (51 ± 8 to 94 ± 22 nl · min-1 · m-2; P = 0.05). Dobutamine infusion did not increase exhaled NO output. We conclude that nasal exhaled NO decreases (and nonnasal exhaled NO increases) with exercise. We also conclude that, under the conditions of this study, increased exhaled NO output during exercise is more closely related to increased ventilation than to increased blood flow.
AB - To define the site of release and factors modulating exhaled nitric oxide (NO) during exercise in humans, we measured exhaled NO output during exercise, during exercise after balloon occlusion of the nasopharynx (to exclude nasal NO), and at rest with isocapneic hyperventilation or dobutamine infusion. Exhaled NO output increased from rest to exercise (57 ± 10 to 171 ± 30 nl · min-1 · m-2; p < 0.003; n = 8). Exclusion of nasal NO reduced exhaled NO at rest and during exercise. Calculated nasal contribution at rest (53 ± 5%) decreased during exercise (29 ± 6%; P < 0.05), whereas nonnasal contribution increased (47 ± 5 to 71 ± 6%; P < 0.05). Isocapneic hyperventilation at rest increased exhaled NO output (51 ± 8 to 94 ± 22 nl · min-1 · m-2; P = 0.05). Dobutamine infusion did not increase exhaled NO output. We conclude that nasal exhaled NO decreases (and nonnasal exhaled NO increases) with exercise. We also conclude that, under the conditions of this study, increased exhaled NO output during exercise is more closely related to increased ventilation than to increased blood flow.
KW - nasal
KW - nose
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U2 - 10.1152/jappl.1996.80.6.1865
DO - 10.1152/jappl.1996.80.6.1865
M3 - Article
C2 - 8806888
AN - SCOPUS:0030054692
SN - 8750-7587
VL - 80
SP - 1865
EP - 1871
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 6
ER -