Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy

A. L. Schwartz, Motomi (Tomi) Mori, R. Gao, Lillian Nail, M. E. King

Research output: Contribution to journalArticle

218 Citations (Scopus)

Abstract

SCHWARTZ, A. L., M. MORI, R. GAO, L. M. NAIL, and M. E. KING. Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med. Sci. Sports Exerc., Vol. 33, No. 5, 2001, pp. 000-000. Purpose: Cancer treatment-related fatigue is the most prevalent and distressing symptom of cancer therapy. Interventions to minimize fatigue are needed. The purpose of this study was to examine the relationship between exercise and fatigue over the first three cycles of chemotherapy in women receiving either cyclophosphamide, methotrexate, and fluorouracil (CMF) or doxorubicin and cyclophosphamide (AC) for breast cancer. Methods: Seventy-two newly diagnosed women with breast cancer were instructed in a home-based moderate-intensity exercise intervention. Measures of functional ability, energy expenditure, and fatigue were obtained at baseline and posttest. Subjects maintained daily records of four types of fatigue, and exercise duration, intensity, and type. Results: Exercise significantly reduced all four levels of fatigue (P <0.01). As the duration of exercise increased, the intensity of fatigue declined (P <0.01). There was a significant carry-over effect of exercise on fatigue, but the effect lasted only 1 d. The level of fatigue at study entry was not associated with number of days of exercise or amount of exercise a woman engaged in. Conclusions: The impact of exercise on fatigue was significant and suggests the effectiveness of a low- to moderate-intensity regular exercise program in maintaining functional ability and reducing fatigue in women with breast cancer receiving chemotherapy.

Original languageEnglish (US)
Pages (from-to)718-723
Number of pages6
JournalMedicine and Science in Sports and Exercise
Volume33
Issue number5
StatePublished - 2001

Fingerprint

Fatigue
Exercise
Breast Neoplasms
Drug Therapy
Cyclophosphamide
Morus
Second Primary Neoplasms
Nails
Methotrexate
Fluorouracil
Doxorubicin
Energy Metabolism
Sports

Keywords

  • Cancer-related fatique
  • Chemotherapy
  • Unbalanced repeated measures

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine

Cite this

Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. / Schwartz, A. L.; Mori, Motomi (Tomi); Gao, R.; Nail, Lillian; King, M. E.

In: Medicine and Science in Sports and Exercise, Vol. 33, No. 5, 2001, p. 718-723.

Research output: Contribution to journalArticle

Schwartz, A. L. ; Mori, Motomi (Tomi) ; Gao, R. ; Nail, Lillian ; King, M. E. / Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. In: Medicine and Science in Sports and Exercise. 2001 ; Vol. 33, No. 5. pp. 718-723.
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