Abstract
SCHWARTZ, A. L., M. MORI, R. GAO, L. M. NAIL, and M. E. KING. Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med. Sci. Sports Exerc., Vol. 33, No. 5, 2001, pp. 000-000. Purpose: Cancer treatment-related fatigue is the most prevalent and distressing symptom of cancer therapy. Interventions to minimize fatigue are needed. The purpose of this study was to examine the relationship between exercise and fatigue over the first three cycles of chemotherapy in women receiving either cyclophosphamide, methotrexate, and fluorouracil (CMF) or doxorubicin and cyclophosphamide (AC) for breast cancer. Methods: Seventy-two newly diagnosed women with breast cancer were instructed in a home-based moderate-intensity exercise intervention. Measures of functional ability, energy expenditure, and fatigue were obtained at baseline and posttest. Subjects maintained daily records of four types of fatigue, and exercise duration, intensity, and type. Results: Exercise significantly reduced all four levels of fatigue (P <0.01). As the duration of exercise increased, the intensity of fatigue declined (P <0.01). There was a significant carry-over effect of exercise on fatigue, but the effect lasted only 1 d. The level of fatigue at study entry was not associated with number of days of exercise or amount of exercise a woman engaged in. Conclusions: The impact of exercise on fatigue was significant and suggests the effectiveness of a low- to moderate-intensity regular exercise program in maintaining functional ability and reducing fatigue in women with breast cancer receiving chemotherapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 718-723 |
| Number of pages | 6 |
| Journal | Medicine and Science in Sports and Exercise |
| Volume | 33 |
| Issue number | 5 |
| State | Published - 2001 |
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Keywords
- Cancer-related fatique
- Chemotherapy
- Unbalanced repeated measures
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Physical Therapy, Sports Therapy and Rehabilitation
- Orthopedics and Sports Medicine
Cite this
Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. / Schwartz, A. L.; Mori, Motomi (Tomi); Gao, R.; Nail, Lillian; King, M. E.
In: Medicine and Science in Sports and Exercise, Vol. 33, No. 5, 2001, p. 718-723.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy
AU - Schwartz, A. L.
AU - Mori, Motomi (Tomi)
AU - Gao, R.
AU - Nail, Lillian
AU - King, M. E.
PY - 2001
Y1 - 2001
N2 - SCHWARTZ, A. L., M. MORI, R. GAO, L. M. NAIL, and M. E. KING. Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med. Sci. Sports Exerc., Vol. 33, No. 5, 2001, pp. 000-000. Purpose: Cancer treatment-related fatigue is the most prevalent and distressing symptom of cancer therapy. Interventions to minimize fatigue are needed. The purpose of this study was to examine the relationship between exercise and fatigue over the first three cycles of chemotherapy in women receiving either cyclophosphamide, methotrexate, and fluorouracil (CMF) or doxorubicin and cyclophosphamide (AC) for breast cancer. Methods: Seventy-two newly diagnosed women with breast cancer were instructed in a home-based moderate-intensity exercise intervention. Measures of functional ability, energy expenditure, and fatigue were obtained at baseline and posttest. Subjects maintained daily records of four types of fatigue, and exercise duration, intensity, and type. Results: Exercise significantly reduced all four levels of fatigue (P <0.01). As the duration of exercise increased, the intensity of fatigue declined (P <0.01). There was a significant carry-over effect of exercise on fatigue, but the effect lasted only 1 d. The level of fatigue at study entry was not associated with number of days of exercise or amount of exercise a woman engaged in. Conclusions: The impact of exercise on fatigue was significant and suggests the effectiveness of a low- to moderate-intensity regular exercise program in maintaining functional ability and reducing fatigue in women with breast cancer receiving chemotherapy.
AB - SCHWARTZ, A. L., M. MORI, R. GAO, L. M. NAIL, and M. E. KING. Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med. Sci. Sports Exerc., Vol. 33, No. 5, 2001, pp. 000-000. Purpose: Cancer treatment-related fatigue is the most prevalent and distressing symptom of cancer therapy. Interventions to minimize fatigue are needed. The purpose of this study was to examine the relationship between exercise and fatigue over the first three cycles of chemotherapy in women receiving either cyclophosphamide, methotrexate, and fluorouracil (CMF) or doxorubicin and cyclophosphamide (AC) for breast cancer. Methods: Seventy-two newly diagnosed women with breast cancer were instructed in a home-based moderate-intensity exercise intervention. Measures of functional ability, energy expenditure, and fatigue were obtained at baseline and posttest. Subjects maintained daily records of four types of fatigue, and exercise duration, intensity, and type. Results: Exercise significantly reduced all four levels of fatigue (P <0.01). As the duration of exercise increased, the intensity of fatigue declined (P <0.01). There was a significant carry-over effect of exercise on fatigue, but the effect lasted only 1 d. The level of fatigue at study entry was not associated with number of days of exercise or amount of exercise a woman engaged in. Conclusions: The impact of exercise on fatigue was significant and suggests the effectiveness of a low- to moderate-intensity regular exercise program in maintaining functional ability and reducing fatigue in women with breast cancer receiving chemotherapy.
KW - Cancer-related fatique
KW - Chemotherapy
KW - Unbalanced repeated measures
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UR - http://www.scopus.com/inward/citedby.url?scp=0035059801&partnerID=8YFLogxK
M3 - Article
C2 - 11323538
AN - SCOPUS:0035059801
VL - 33
SP - 718
EP - 723
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
SN - 0195-9131
IS - 5
ER -