Exercise is Associated with Increased Small HDL Particle Concentration and Decreased Vascular Stiffness in Rheumatoid Arthritis

Kevin W. Byram, Annette M. Oeser, Macrae F. Linton, Sergio Fazio, C. Michael Stein, Michelle J. Ormseth

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Objective Patients with rheumatoid arthritis (RA) have increased cardiovascular (CV) risk. In the general population, exercise improves several CV risk factors. In a cross-sectional study, we examined the hypothesis that more exercise is associated with protective traditional and non-traditional CV risk factor profile in patients with RA. Methods Patient-reported exercise outside of daily activities was quantified by time and metabolic equivalents per week (METmin/week) and CV risk factors including blood pressure, standard lipid profiles, lipoprotein particle concentrations (NMR spectroscopy), and vascular indices were measured in 165 patients with RA. The relationship between exercise and CV risk factors was assessed according to whether patients exercised or not, and after adjustment for age, race and sex. Results Over half (54%) of RA patients did not exercise. Among those who did exercise, median value for exercise duration was 113 min/week [IQR: 60, 210], and exercise metabolic equivalent expenditure was 484 METmin/week [IQR: 258, 990]. Disease activity (measured by DAS28 score), C-reactive protein, waist-hip ratio, and prevalence of hypertension were lower in patients who exercised compared to those who did not (all p-values < 0.05) but standard lipid profile and body mass index were not significantly different. Patients who exercised had significantly higher concentrations of HDL particles (p = 0.004) and lower vascular stiffness as measured by pulse wave velocity (p = 0.005). Conclusions More self-reported exercise in patients with RA was associated with a protective CV risk factor profile including lower waist-hip ratio, higher HDL particle concentration, lower vascular stiffness, and a lower prevalence of hypertension.

    Original languageEnglish (US)
    Pages (from-to)417-421
    Number of pages5
    JournalJournal of Clinical Rheumatology
    Volume24
    Issue number8
    DOIs
    StatePublished - Dec 1 2018

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    Vascular Stiffness
    Rheumatoid Arthritis
    Exercise
    Metabolic Equivalent
    Waist-Hip Ratio
    Hypertension
    Lipids
    Pulse Wave Analysis
    Health Expenditures
    C-Reactive Protein
    Lipoproteins
    Blood Vessels
    Body Mass Index
    Magnetic Resonance Spectroscopy
    Cross-Sectional Studies
    Blood Pressure

    Keywords

    • cardiovascular diseases
    • cholesterol
    • exercise
    • HDL
    • rheumatoid arthritis

    ASJC Scopus subject areas

    • Rheumatology

    Cite this

    Exercise is Associated with Increased Small HDL Particle Concentration and Decreased Vascular Stiffness in Rheumatoid Arthritis. / Byram, Kevin W.; Oeser, Annette M.; Linton, Macrae F.; Fazio, Sergio; Stein, C. Michael; Ormseth, Michelle J.

    In: Journal of Clinical Rheumatology, Vol. 24, No. 8, 01.12.2018, p. 417-421.

    Research output: Contribution to journalArticle

    Byram, Kevin W. ; Oeser, Annette M. ; Linton, Macrae F. ; Fazio, Sergio ; Stein, C. Michael ; Ormseth, Michelle J. / Exercise is Associated with Increased Small HDL Particle Concentration and Decreased Vascular Stiffness in Rheumatoid Arthritis. In: Journal of Clinical Rheumatology. 2018 ; Vol. 24, No. 8. pp. 417-421.
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    abstract = "Objective Patients with rheumatoid arthritis (RA) have increased cardiovascular (CV) risk. In the general population, exercise improves several CV risk factors. In a cross-sectional study, we examined the hypothesis that more exercise is associated with protective traditional and non-traditional CV risk factor profile in patients with RA. Methods Patient-reported exercise outside of daily activities was quantified by time and metabolic equivalents per week (METmin/week) and CV risk factors including blood pressure, standard lipid profiles, lipoprotein particle concentrations (NMR spectroscopy), and vascular indices were measured in 165 patients with RA. The relationship between exercise and CV risk factors was assessed according to whether patients exercised or not, and after adjustment for age, race and sex. Results Over half (54{\%}) of RA patients did not exercise. Among those who did exercise, median value for exercise duration was 113 min/week [IQR: 60, 210], and exercise metabolic equivalent expenditure was 484 METmin/week [IQR: 258, 990]. Disease activity (measured by DAS28 score), C-reactive protein, waist-hip ratio, and prevalence of hypertension were lower in patients who exercised compared to those who did not (all p-values < 0.05) but standard lipid profile and body mass index were not significantly different. Patients who exercised had significantly higher concentrations of HDL particles (p = 0.004) and lower vascular stiffness as measured by pulse wave velocity (p = 0.005). Conclusions More self-reported exercise in patients with RA was associated with a protective CV risk factor profile including lower waist-hip ratio, higher HDL particle concentration, lower vascular stiffness, and a lower prevalence of hypertension.",
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    AU - Fazio, Sergio

    AU - Stein, C. Michael

    AU - Ormseth, Michelle J.

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