Exercise induced augmentation of cellular and humoral autoimmunity associated with increased cardiac dilatation in experimental autoimmune myocarditis

Jeffrey D. Hosenpud; Stephen M. Campbell; Nelson (Sam) Niles; Jane Lee; David Mendelson; Mark V. Hart

doi:10.1093/cvrese/21.3.217

Exercise induced augmentation of cellular and humoral autoimmunity associated with increased cardiac dilatation in experimental autoimmune myocarditis

Jeffrey D. Hosenpud, Stephen M. Campbell, Nelson (Sam) Niles, Jane Lee, David Mendelson, Mark V. Hart

Oral Pathology

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Abstract

Summary: To determine the effects of exercise in experimental autoimmune myocarditis, Guinea pigs immunised with heterologous heart protein (rat heart), Freund's complete adjuvant, and pertussis vaccine (treated group) were exercised on a treadmill for a total of 11 weeks and compared with non-exercise treated animals. In vivo heart rates and pressures, in vitro left ventricular pressure-volume relations, myocardial histology, circulating antiheart antibody, and in vitro lymphocyte stimulation were determined. Exercise resulted in increased cardiac dilatation in treated animals as assessed by in vitro left ventricular pressure-volume relations compared with non-exercise treated animals (at 8 mmHg 1.41(0.17) ml·kg^-1 vs 1.20(0.17) ml·kg^-1 respectively, p

Original language	English (US)
Pages (from-to)	217-222
Number of pages	6
Journal	Cardiovascular Research
Volume	21
Issue number	3
DOIs	https://doi.org/10.1093/cvrese/21.3.217
State	Published - Mar 1987

Keywords

Animal model
Autoimmune
Exercise
Myocarditis

ASJC Scopus subject areas

Statistics, Probability and Uncertainty
Applied Mathematics
Physiology (medical)
Physiology
Cardiology and Cardiovascular Medicine

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10.1093/cvrese/21.3.217

Cite this

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abstract = "Summary: To determine the effects of exercise in experimental autoimmune myocarditis, Guinea pigs immunised with heterologous heart protein (rat heart), Freund's complete adjuvant, and pertussis vaccine (treated group) were exercised on a treadmill for a total of 11 weeks and compared with non-exercise treated animals. In vivo heart rates and pressures, in vitro left ventricular pressure-volume relations, myocardial histology, circulating antiheart antibody, and in vitro lymphocyte stimulation were determined. Exercise resulted in increased cardiac dilatation in treated animals as assessed by in vitro left ventricular pressure-volume relations compared with non-exercise treated animals (at 8 mmHg 1.41(0.17) ml·kg-1 vs 1.20(0.17) ml·kg-1 respectively, p",

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AU - Mendelson, David

AU - Hart, Mark V.

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AB - Summary: To determine the effects of exercise in experimental autoimmune myocarditis, Guinea pigs immunised with heterologous heart protein (rat heart), Freund's complete adjuvant, and pertussis vaccine (treated group) were exercised on a treadmill for a total of 11 weeks and compared with non-exercise treated animals. In vivo heart rates and pressures, in vitro left ventricular pressure-volume relations, myocardial histology, circulating antiheart antibody, and in vitro lymphocyte stimulation were determined. Exercise resulted in increased cardiac dilatation in treated animals as assessed by in vitro left ventricular pressure-volume relations compared with non-exercise treated animals (at 8 mmHg 1.41(0.17) ml·kg-1 vs 1.20(0.17) ml·kg-1 respectively, p

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Exercise induced augmentation of cellular and humoral autoimmunity associated with increased cardiac dilatation in experimental autoimmune myocarditis

Abstract

Keywords

ASJC Scopus subject areas

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