Exercise induced augmentation of cellular and humoral autoimmunity associated with increased cardiac dilatation in experimental autoimmune myocarditis

Jeffrey D. Hosenpud, Stephen M. Campbell, Nelson (Sam) Niles, Jane Lee, David Mendelson, Mark V. Hart

Research output: Contribution to journalArticle

Abstract

Summary: To determine the effects of exercise in experimental autoimmune myocarditis, Guinea pigs immunised with heterologous heart protein (rat heart), Freund's complete adjuvant, and pertussis vaccine (treated group) were exercised on a treadmill for a total of 11 weeks and compared with non-exercise treated animals. In vivo heart rates and pressures, in vitro left ventricular pressure-volume relations, myocardial histology, circulating antiheart antibody, and in vitro lymphocyte stimulation were determined. Exercise resulted in increased cardiac dilatation in treated animals as assessed by in vitro left ventricular pressure-volume relations compared with non-exercise treated animals (at 8 mmHg 1.41(0.17) ml·kg-1 vs 1.20(0.17) ml·kg-1 respectively, p

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalCardiovascular Research
Volume21
Issue number3
DOIs
StatePublished - Mar 1987

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Keywords

  • Animal model
  • Autoimmune
  • Exercise
  • Myocarditis

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Cardiology and Cardiovascular Medicine

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