Exclusion of malignancy in thyroid nodules with indeterminate fine-needle aspiration cytology after negative 18f-fluorodeoxyglucose positron emission tomography: Interim analysis

Amber L. Traugott, Farrokh Dehdashti, Kathryn Trinkaus, Mark Cohen, Elizabeth Fialkowski, Frank Quayle, Hameda Hussain, Rosa Davila, Lourdes Ylagan, Jeffrey F. Moley

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Abstract

Background In all, 20% of fine-needle aspiration (FNA) biopsies of thyroid nodules have an indeterminate diagnosis; of these, 80% are found to be benign after thyroidectomy. Some previous reports indicate that positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) imaging may predict malignancy status. We now report results on the first 51 patients in the largest prospective study of FDG-PET in patients with an indeterminate thyroid nodule FNA. Methods Eligible patients had a dominant thyroid nodule that was palpable or ≥1 cm in greatest dimension as seen by ultrasonography, and indeterminate histology of the FNA biopsy specimen. Participants underwent preoperative neck FDG-PET alone or FDG-PET with computed tomography (FDG-PET/CT). Images were evaluated qualitatively and semiquantitatively using the maximum standardized uptake value (SUVmax). Final diagnosis was determined by histopathologic analysis after thyroidectomy. Descriptive statistical analysis was performed. Results A total of 51 patients underwent preoperative FDG-PET or FDG-PET/CT. Studies without focally increased uptake localized to the lesion were considered negative. For all lesions (10 malignant, 41 benign), the sensitivity, specificity, positive-predictive value (PPV), and negative-predictive value (NPV) were 80%, 61%, 33%, and 93%, respectively. Postoperatively, two malignant and six benign lesions were found to be

Original languageEnglish (US)
Pages (from-to)1247-1253
Number of pages7
JournalWorld Journal of Surgery
Volume34
Issue number6
DOIs
StatePublished - Jun 2010
Externally publishedYes

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Thyroid Nodule
Fluorodeoxyglucose F18
Fine Needle Biopsy
Positron-Emission Tomography
Cell Biology
Thyroidectomy
Neoplasms
Ultrasonography
Histology
Neck
Prospective Studies
Sensitivity and Specificity

ASJC Scopus subject areas

  • Surgery

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Exclusion of malignancy in thyroid nodules with indeterminate fine-needle aspiration cytology after negative 18f-fluorodeoxyglucose positron emission tomography : Interim analysis. / Traugott, Amber L.; Dehdashti, Farrokh; Trinkaus, Kathryn; Cohen, Mark; Fialkowski, Elizabeth; Quayle, Frank; Hussain, Hameda; Davila, Rosa; Ylagan, Lourdes; Moley, Jeffrey F.

In: World Journal of Surgery, Vol. 34, No. 6, 06.2010, p. 1247-1253.

Research output: Contribution to journalArticle

Traugott, Amber L. ; Dehdashti, Farrokh ; Trinkaus, Kathryn ; Cohen, Mark ; Fialkowski, Elizabeth ; Quayle, Frank ; Hussain, Hameda ; Davila, Rosa ; Ylagan, Lourdes ; Moley, Jeffrey F. / Exclusion of malignancy in thyroid nodules with indeterminate fine-needle aspiration cytology after negative 18f-fluorodeoxyglucose positron emission tomography : Interim analysis. In: World Journal of Surgery. 2010 ; Vol. 34, No. 6. pp. 1247-1253.
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abstract = "Background In all, 20{\%} of fine-needle aspiration (FNA) biopsies of thyroid nodules have an indeterminate diagnosis; of these, 80{\%} are found to be benign after thyroidectomy. Some previous reports indicate that positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) imaging may predict malignancy status. We now report results on the first 51 patients in the largest prospective study of FDG-PET in patients with an indeterminate thyroid nodule FNA. Methods Eligible patients had a dominant thyroid nodule that was palpable or ≥1 cm in greatest dimension as seen by ultrasonography, and indeterminate histology of the FNA biopsy specimen. Participants underwent preoperative neck FDG-PET alone or FDG-PET with computed tomography (FDG-PET/CT). Images were evaluated qualitatively and semiquantitatively using the maximum standardized uptake value (SUVmax). Final diagnosis was determined by histopathologic analysis after thyroidectomy. Descriptive statistical analysis was performed. Results A total of 51 patients underwent preoperative FDG-PET or FDG-PET/CT. Studies without focally increased uptake localized to the lesion were considered negative. For all lesions (10 malignant, 41 benign), the sensitivity, specificity, positive-predictive value (PPV), and negative-predictive value (NPV) were 80{\%}, 61{\%}, 33{\%}, and 93{\%}, respectively. Postoperatively, two malignant and six benign lesions were found to be",
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T2 - Interim analysis

AU - Traugott, Amber L.

AU - Dehdashti, Farrokh

AU - Trinkaus, Kathryn

AU - Cohen, Mark

AU - Fialkowski, Elizabeth

AU - Quayle, Frank

AU - Hussain, Hameda

AU - Davila, Rosa

AU - Ylagan, Lourdes

AU - Moley, Jeffrey F.

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N2 - Background In all, 20% of fine-needle aspiration (FNA) biopsies of thyroid nodules have an indeterminate diagnosis; of these, 80% are found to be benign after thyroidectomy. Some previous reports indicate that positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) imaging may predict malignancy status. We now report results on the first 51 patients in the largest prospective study of FDG-PET in patients with an indeterminate thyroid nodule FNA. Methods Eligible patients had a dominant thyroid nodule that was palpable or ≥1 cm in greatest dimension as seen by ultrasonography, and indeterminate histology of the FNA biopsy specimen. Participants underwent preoperative neck FDG-PET alone or FDG-PET with computed tomography (FDG-PET/CT). Images were evaluated qualitatively and semiquantitatively using the maximum standardized uptake value (SUVmax). Final diagnosis was determined by histopathologic analysis after thyroidectomy. Descriptive statistical analysis was performed. Results A total of 51 patients underwent preoperative FDG-PET or FDG-PET/CT. Studies without focally increased uptake localized to the lesion were considered negative. For all lesions (10 malignant, 41 benign), the sensitivity, specificity, positive-predictive value (PPV), and negative-predictive value (NPV) were 80%, 61%, 33%, and 93%, respectively. Postoperatively, two malignant and six benign lesions were found to be

AB - Background In all, 20% of fine-needle aspiration (FNA) biopsies of thyroid nodules have an indeterminate diagnosis; of these, 80% are found to be benign after thyroidectomy. Some previous reports indicate that positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) imaging may predict malignancy status. We now report results on the first 51 patients in the largest prospective study of FDG-PET in patients with an indeterminate thyroid nodule FNA. Methods Eligible patients had a dominant thyroid nodule that was palpable or ≥1 cm in greatest dimension as seen by ultrasonography, and indeterminate histology of the FNA biopsy specimen. Participants underwent preoperative neck FDG-PET alone or FDG-PET with computed tomography (FDG-PET/CT). Images were evaluated qualitatively and semiquantitatively using the maximum standardized uptake value (SUVmax). Final diagnosis was determined by histopathologic analysis after thyroidectomy. Descriptive statistical analysis was performed. Results A total of 51 patients underwent preoperative FDG-PET or FDG-PET/CT. Studies without focally increased uptake localized to the lesion were considered negative. For all lesions (10 malignant, 41 benign), the sensitivity, specificity, positive-predictive value (PPV), and negative-predictive value (NPV) were 80%, 61%, 33%, and 93%, respectively. Postoperatively, two malignant and six benign lesions were found to be

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