Exclusion of dominant mutations within the FTDP-17 locus on chromosome 17 for Parkinson's disease

Sepideh Zareparsi, Karin Wirdefeldt, Catherine E. Burgess, John Nutt, Patricia Kramer, Martin Schalling, Haydeh Payami

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Parkinson's disease (PD) is a prevalent movement disorder, and 10-30% of PD is familial. Several neurodegenerative disorders which are collectively called frontotemporal dementia and parkinsonism have been mapped to chromosome 17q and mutations in tau have been identified. The clinical and pathological overlap suggests that these related conditions may be due to mutations in tau. We examined linkage to the candidate region on chromosome 17 including and surrounding tau in eight familial PD kindreds. We found no evidence for linkage and excluded the 6cM candidate region which suggest that in our families, PD is not caused by dominant mutations within tau. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)140-142
Number of pages3
JournalNeuroscience Letters
Volume272
Issue number2
DOIs
StatePublished - Sep 10 1999

Keywords

  • Chromosome 17
  • Frontotemporal dementia and parkinsonism
  • Genetics
  • Linkage
  • Parkinson'
  • Tau
  • s disease

ASJC Scopus subject areas

  • Neuroscience(all)

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    Zareparsi, S., Wirdefeldt, K., Burgess, C. E., Nutt, J., Kramer, P., Schalling, M., & Payami, H. (1999). Exclusion of dominant mutations within the FTDP-17 locus on chromosome 17 for Parkinson's disease. Neuroscience Letters, 272(2), 140-142. https://doi.org/10.1016/S0304-3940(99)00581-9