Exclusion of autosomal dominant dystonia gene from large regions of chromosomes 11p, 13q, and 21q by multi-point linkage analysis

P. L. Kramer, L. Ozelius, J. F. Gusella, S. Fahn, K. K. Kidd, X. O. Breakefield

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Multi-point linkage analyses of autosomal dominant form of torsion dystonia with linkage groups on chromosomes 11p, 13q, 21q are reported. Analyses are based on family data from a single, large, non-Jewish pedigree. Large portions of chromosomes 11p and 13q, and virtually the entire long arm of chromosome 21 are excluded from linkage with dystonia. Practical aspects of designing multipoint analyses are discussed.

Original languageEnglish (US)
Pages (from-to)377-386
Number of pages10
JournalGenetic Epidemiology
Volume4
Issue number5
StatePublished - 1987
Externally publishedYes

Fingerprint

Dominant Genes
Dystonia
Chromosomes
Dystonia Musculorum Deformans
Chromosomes, Human, Pair 21
Pedigree

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

Cite this

Kramer, P. L., Ozelius, L., Gusella, J. F., Fahn, S., Kidd, K. K., & Breakefield, X. O. (1987). Exclusion of autosomal dominant dystonia gene from large regions of chromosomes 11p, 13q, and 21q by multi-point linkage analysis. Genetic Epidemiology, 4(5), 377-386.

Exclusion of autosomal dominant dystonia gene from large regions of chromosomes 11p, 13q, and 21q by multi-point linkage analysis. / Kramer, P. L.; Ozelius, L.; Gusella, J. F.; Fahn, S.; Kidd, K. K.; Breakefield, X. O.

In: Genetic Epidemiology, Vol. 4, No. 5, 1987, p. 377-386.

Research output: Contribution to journalArticle

Kramer, PL, Ozelius, L, Gusella, JF, Fahn, S, Kidd, KK & Breakefield, XO 1987, 'Exclusion of autosomal dominant dystonia gene from large regions of chromosomes 11p, 13q, and 21q by multi-point linkage analysis', Genetic Epidemiology, vol. 4, no. 5, pp. 377-386.
Kramer, P. L. ; Ozelius, L. ; Gusella, J. F. ; Fahn, S. ; Kidd, K. K. ; Breakefield, X. O. / Exclusion of autosomal dominant dystonia gene from large regions of chromosomes 11p, 13q, and 21q by multi-point linkage analysis. In: Genetic Epidemiology. 1987 ; Vol. 4, No. 5. pp. 377-386.
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