Exclusion of autosomal dominant dystonia gene from large regions of chromosomes 11p, 13q, and 21q by multi‐point linkage analysis

P. L. Kramer; L. Ozelius; J. F. Gusella; S. Fahn; K. K. Kidd; X. O. Breakefield; I. B. Boerecki

doi:10.1002/gepi.1370040506

Exclusion of autosomal dominant dystonia gene from large regions of chromosomes 11p, 13q, and 21q by multi‐point linkage analysis

P. L. Kramer, L. Ozelius, J. F. Gusella, S. Fahn, K. K. Kidd, X. O. Breakefield, I. B. Boerecki

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Multi‐point linkage analyses of autosomal dominant form of torsion dystonia with linkage groups on chromosomes 11p, 13q, 21q are reported. Analyses are based on family data from a single, large, non‐Jewish pedigree. Large portions of chromosomes 11p and 13q, and virtually the entire long arm of chromosome 21 are excluded from linkage with dystonia. Practical aspects of designing multipoint analyses are discussed.

Original language	English (US)
Pages (from-to)	377-386
Number of pages	10
Journal	Genetic Epidemiology
Volume	4
Issue number	5
DOIs	https://doi.org/10.1002/gepi.1370040506
State	Published - 1987
Externally published	Yes

Keywords

chromosome linkage
gene mapping
multi‐point analysis design
torsion dystonia

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

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10.1002/gepi.1370040506

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title = "Exclusion of autosomal dominant dystonia gene from large regions of chromosomes 11p, 13q, and 21q by multi‐point linkage analysis",

abstract = "Multi‐point linkage analyses of autosomal dominant form of torsion dystonia with linkage groups on chromosomes 11p, 13q, 21q are reported. Analyses are based on family data from a single, large, non‐Jewish pedigree. Large portions of chromosomes 11p and 13q, and virtually the entire long arm of chromosome 21 are excluded from linkage with dystonia. Practical aspects of designing multipoint analyses are discussed.",

keywords = "chromosome linkage, gene mapping, multi‐point analysis design, torsion dystonia",

author = "Kramer, {P. L.} and L. Ozelius and Gusella, {J. F.} and S. Fahn and Kidd, {K. K.} and Breakefield, {X. O.} and Boerecki, {I. B.}",

year = "1987",

doi = "10.1002/gepi.1370040506",

language = "English (US)",

volume = "4",

pages = "377--386",

journal = "Genetic Epidemiology",

issn = "0741-0395",

publisher = "Wiley-Liss Inc.",

number = "5",

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TY - JOUR

T1 - Exclusion of autosomal dominant dystonia gene from large regions of chromosomes 11p, 13q, and 21q by multi‐point linkage analysis

AU - Kramer, P. L.

AU - Ozelius, L.

AU - Gusella, J. F.

AU - Fahn, S.

AU - Kidd, K. K.

AU - Breakefield, X. O.

AU - Boerecki, I. B.

PY - 1987

Y1 - 1987

N2 - Multi‐point linkage analyses of autosomal dominant form of torsion dystonia with linkage groups on chromosomes 11p, 13q, 21q are reported. Analyses are based on family data from a single, large, non‐Jewish pedigree. Large portions of chromosomes 11p and 13q, and virtually the entire long arm of chromosome 21 are excluded from linkage with dystonia. Practical aspects of designing multipoint analyses are discussed.

AB - Multi‐point linkage analyses of autosomal dominant form of torsion dystonia with linkage groups on chromosomes 11p, 13q, 21q are reported. Analyses are based on family data from a single, large, non‐Jewish pedigree. Large portions of chromosomes 11p and 13q, and virtually the entire long arm of chromosome 21 are excluded from linkage with dystonia. Practical aspects of designing multipoint analyses are discussed.

KW - chromosome linkage

KW - gene mapping

KW - multi‐point analysis design

KW - torsion dystonia

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UR - http://www.scopus.com/inward/citedby.url?scp=0023633785&partnerID=8YFLogxK

U2 - 10.1002/gepi.1370040506

DO - 10.1002/gepi.1370040506

M3 - Article

C2 - 3692135

AN - SCOPUS:0023633785

SN - 0741-0395

VL - 4

SP - 377

EP - 386

JO - Genetic Epidemiology

JF - Genetic Epidemiology

IS - 5

ER -

Exclusion of autosomal dominant dystonia gene from large regions of chromosomes 11p, 13q, and 21q by multi‐point linkage analysis

Abstract

Keywords

ASJC Scopus subject areas

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